Project Grant R21CA299812
- This Project Grant award of $148,500 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to evaluate the role of extracellular vesicles in modulating the tumor microenvironment, with a focus on their impact on T cell suppression in non-small cell lung cancer (NSCLC) and prostate cancer. The research is being conducted by the University of North Texas and aims to identify a specific subpopulation of NSCLC-derived extracellular vesicles, called TGN46+...
- This federal Project Grant award of $421,685 from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) supports research to investigate the "reactive" immune system in tumors and the tumor microenvironment. The primary objective is to discover discrete niches within the tumor microenvironment that are conducive to anti-tumor immunity, in order to guide the development of more effective cancer immunotherapies. The research approach combines spatial...
- The federal Project Grant award titled "NAVIGATING PATHWAYS OF INNATE IMMUNITY AND EPIGENETIC MEMORY IN CHECKPOINT IMMUNOTHERAPY" is funded by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396). This $846,982 award to Beth Israel Deaconess Medical Center, Inc. (BIDMC) will support research aimed at understanding the fundamental biological mechanisms underlying cancer development, progression, and potential interventions. The research will...
- This $2,895,540 federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to Duke University will support research to understand and target epigenetic regulation of immune evasion in prostate cancer. The research aims to investigate the role of the epigenetic regulator TNRC18 in shaping the tumor immune microenvironment and sensitizing prostate cancer to immune checkpoint inhibitor therapy. The 4-year project will utilize human and mouse prostate...
- This $632,300 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop an integrated ultra-high-throughput 3D volumetric super-resolution imaging system for studying the tumor microenvironment. The project, led by Carnegie Mellon University, will combine a multiscale fluorescence mesoscope with expansion microscopy to enable rapid, large-area 3D imaging at the subcellular level. This innovative system will allow researchers to visualize...
- This federal Project Grant award of $3,201,530.00 from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports research by the Sloan-Kettering Institute for Cancer Research to investigate the mechanisms underlying extrachromosomal DNA (ecDNA) segregation and repair in cancer. The research aims to understand how the circular topology of ecDNA affects its function and maintenance, including exploring the role of RNA-dependent physical tethering to mitotic...
- This federal Project Grant award, with a total funding amount of $534,083, was provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396). The award supports research at the University of California, San Diego (UCSD) to investigate how breast cancer cell-derived extracellular vesicles can lead to an overproduction of glucocorticoids, or "stress hormones," and how this affects normal cells to facilitate breast cancer metastasis. The key...
- This federal Project Grant award of $714,317 from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) supports research conducted by the Icahn School of Medicine at Mount Sinai to investigate the mechanisms underlying the progression of prostate cancer to a metastatic, castration-resistant state. The research aims to determine how the tumor microenvironment and processes like epithelial-mesenchymal transition and anoikis resistance contribute to prostate...
- This $369,868 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to investigate the role of intercellular mitochondrial transfer between nerves and cancer cells, particularly in the context of triple-negative breast cancer metastasis. The project aims to determine how this mitochondrial transfer impacts the metastatic potential of cancer cells and identify key mediators of the process, with the goal of developing potential...
- This $516,355.74 Project Grant from the National Cancer Institute, part of the Department of Health and Human Services, aims to develop new technologies for immunotherapy monitoring and liquid biopsy through the Cancer Research Manpower federal grant program. Specifically, the Massachusetts General Hospital will utilize the funding to create an ultra-high sensitive platform that can map single extracellular vesicles to parent cells at the single particle level and apply it to profile tumor...
This federal Project Grant award of $429,399 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to Cedars-Sinai Medical Center aims to elucidate the role of extracellular vesicle-enclosed circular RNAs in modulating the immune response to prostate cancer. The study will investigate the transfer of extracellular vesicles from prostate cancer cells to macrophages, quantifying uptake by these target cells, and explore the mechanisms by which the enclosed circular RNAs can modulate macrophage activation and function. The award will support innovative scientific research to enhance understanding of cancer biology and develop potential new immunotherapies that could be combined with standard treatments. The project is structured in two main research aims and is expected to run from August 2025 through July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.4k | 8/14/25 |