Project Grant R37CA299200
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Tufts University School of Medicine a Project Grant of $415,994 under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on Epstein-Barr Virus (EBV)-driven B-cell transformation under germinal center hypoxia. The five-year project, which commenced May 1, 2026 and concludes April 30, 2031, investigates the role of ASAH1-driven ceramide metabolism in EBV-related lymphomagenesis. This...
- Federal Project Grant Award Summary The National Cancer Institute awarded $1.22M to the University of Massachusetts Boston under its Cancer Biology Research program (CFDA 93.396) effective August 1, 2025, through July 31, 2028. This project grant supports fundamental research to advance understanding of extracellular vesicles (EVs)—cell-derived, membrane-bound structures that carry biomolecules and serve as circulating biomarkers for disease diagnosis and therapeutic delivery. The research...
- Federal Grant Award Summary Award Overview: The National Cancer Institute (NCI) awarded Harvard Medical School a Project Grant of $237,023 on March 13, 2026, under the Cancer Biology Research program (CFDA 93.396) to support research through February 28, 2029. The award funds development of high-throughput technological tools to track the fate and dynamics of prematurely terminated transcripts in cancer cells, with performance conducted in Boston, Massachusetts. Research Deliverables: The...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Emory University $646,181 under the Cancer Biology Research program (CFDA 93.396) on April 2, 2026, to fund a five-year research project examining the role of clonal hematopoiesis (CH) in lung cancer development. The project delivers fundamental research on how age-related CH mutations drive non-small cell lung cancer (NSCLC) by suppressing anti-tumor immune responses, with specific focus on regulatory B cells...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Tufts University School of Medicine a Project Grant totaling $433,759 under the Cancer Biology Research program (CFDA 93.396) to investigate mechanisms of prostate cancer reactivation from dormancy in the bone marrow microenvironment. The research will deliver fundamental scientific knowledge on how osteoclasts activate dormant disseminated tumor cells (DTCs) through tunneling nanotubes (TNTs)—membranous...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $394,214 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded on May 19, 2026, with completion targeted for April 30, 2028. This revised R21 application responds to the co-infections and cancer funding opportunity (PAR-23-056) and focuses on developing innovative research models for Epstein-Barr virus (EBV)-driven solid tumors. The...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $561,407 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded on June 18, 2026, with a completion date of May 31, 2031. This grant funds fundamental research into the causal mechanisms driving germline predisposition to myeloproliferative neoplasms (MPNs), specifically investigating how common genetic variants identified through genome-wide association...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded University of Massachusetts Medical School a Project Grant totaling $622,611 under the Cancer Treatment Research program (CFDA 93.395) on June 1, 2026, with completion targeted for May 31, 2031. The research project, "Creating Cancer-Specific Genotoxicity by Targeting Cas9 Nickase to Focal Gene Amplifications," develops and evaluates a novel therapeutic approach using Cas9 nickase technology to...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Dana-Farber Cancer Institute, Inc. a Project Grant of $718,275 under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2026, through June 30, 2031. This award supports fundamental research investigating context-specific pathway dependencies of nuclear envelope (NE) proteins in brain cancer. The research employs a large-scale analysis framework called WEBSTER to assess how NE-associated proteins...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $687,291 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective July 1, 2026 through June 30, 2031. The award funds fundamental research investigating how cancer driver mutations—specifically MLL3 (also known as KMT2C) loss combined with PI3KCA activation and P53 inactivation—promote immune suppression in breast cancer through regulatory T (Treg) cell...
Tufts University School of Medicine received a $415,994 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective May 1, 2026, with a completion date of April 30, 2031. The research project, titled "The Role of ASAH1-Driven Ceramide Metabolism in EBV B-Cell Transformation Under Physiologically Relevant Germinal Center Hypoxia," aims to investigate novel therapeutic targets for Epstein-Barr Virus (EBV)-driven lymphomagenesis in immunocompromised individuals. The project focuses on understanding how EBV reprograms B-cell metabolism during transformation, with particular emphasis on ceramide metabolic pathways and the role of the ASAH1 enzyme within the hypoxic microenvironment of germinal centers where EBV-associated lymphomas typically originate. This fundamental cancer biology research supports the NCI's objective to provide information on cancer causes and mechanisms with the expectation of developing improved prevention, detection, diagnosis, and treatment methods for neoplastic diseases. By targeting virus-driven metabolic pathways rather than relying on nonspecific high-intensity chemotherapy and rituximab approaches, the research addresses a significant clinical need to develop more effective therapies with reduced side effects for EBV-related lymphomas, which are typically aggressive and treatment-resistant in vulnerable populations.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/1/26 | ||
| Not listed | $416.0k | 4/21/26 |