Project Grant R01CA312954
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Albert Einstein College of Medicine a $680,121 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective April 1, 2026, through March 31, 2031, to investigate immunoevasion mechanisms in basal-like breast cancer (BLBC) precancer stem cells. The research focuses on understanding how precancerous stem-like cells (pre-CSCs) escape immune surveillance through the SOX9-B7X immune checkpoint pathway, with...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $561,407 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded on June 18, 2026, with a completion date of May 31, 2031. This grant funds fundamental research into the causal mechanisms driving germline predisposition to myeloproliferative neoplasms (MPNs), specifically investigating how common genetic variants identified through genome-wide association...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $431,970 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded July 1, 2026, with completion targeted for June 30, 2028. The award supports development and validation of TDAM (Tumor Microenvironment of Metastasis Doorway Activity-MRI), a non-invasive magnetic resonance imaging technique designed to detect and measure cancer cell...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $692,197 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective May 1, 2026, through April 30, 2031. The award supports research and development of MTAP (methylthioadenosine phosphorylase) transition state analog inhibitors as a novel synthetic-lethal therapeutic approach for cancer treatment. The research focuses on developing highly specific,...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $431,970 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) to investigate mechanisms of resistance to anti-TROP2 (tumor-associated glycoprotein 2) antibody-drug conjugates, specifically sacituzumab govitecan (SG). The award, effective April 1, 2026 through March 31, 2028, supports the development and characterization of novel humanized TROP2 mouse...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $149,190 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) on December 18, 2025, with an ultimate completion date of September 19, 2027. This award supports biomedical research training and workforce development in cancer research aligned with the National Cancer Program. The grant funds research focused on "Biomechanical Regulation of...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $431,970 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective April 1, 2026, through March 31, 2028. This award supports research investigating dual-targeting therapeutic approaches for acute myeloid leukemia (AML), combining BCL-2 inhibition with CD123-directed natural killer (NK) cell engager technology. The research will evaluate the combinatorial...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $199,584 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective May 1, 2026, through April 30, 2031. This award supports research and training activities examining the relationship between neighborhood disadvantage and obesity-related cancer (ORC) incidence in U.S. Hispanic/Latino populations. The project leverages data from the Hispanic Community...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $431,970 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) to develop and evaluate innovative immunotherapy approaches for treating glioblastoma multiforme (GBM). The award, issued June 24, 2026, with a completion date of May 31, 2028, supports research into Listeria-based immunotherapy combined with gemcitabine chemotherapy as a novel tumor-targeted...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $168,000 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) for the period April 1, 2026 through March 31, 2028. The award supports research to investigate dormancy mechanisms in pancreatic ductal adenocarcinoma (PDAC) and identify therapeutic targets to improve patient survival outcomes. The project focuses on understanding how disseminated tumor cells...
Albert Einstein College of Medicine received a $687,291 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective July 1, 2026 through June 30, 2031. The award funds fundamental research investigating how cancer driver mutations—specifically MLL3 (also known as KMT2C) loss combined with PI3KCA activation and P53 inactivation—promote immune suppression in breast cancer through regulatory T (Treg) cell recruitment and differentiation. The research deliverables include the development and application of genetically engineered mouse models (GEMMs) generated through custom genome editing of mouse mammary stem cells to create immunocompetent tumor models that recapitulate the most frequently occurring driver mutation combinations observed in human breast cancers, with the ultimate objective of identifying novel therapeutic targets to enhance breast cancer immunotherapy efficacy. This project addresses a critical gap in understanding molecular mechanisms of immunosuppression in clinically aggressive breast tumors and represents a proof-of-principle platform for generating clinically relevant cancer models applicable to combination driver mutations. The research is expected to advance fundamental knowledge of cancer immunology and tumor-immune interactions, with potential implications for developing customizable approaches to identify immunosuppressive mechanisms across distinct cancer subtypes. The work will be conducted at Albert Einstein College of Medicine's facilities in the Bronx, New York.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $687.3k | 6/30/26 |