This $622,984 federal Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) supports a multi-year research initiative led by the University of California, Los Angeles (UCLA) to develop a non-invasive imaging approach for functional, metabolic phenotyping of pancreatic ductal adenocarcinoma (PDAC). The research aims to characterize the PDAC tumor microenvironment and tumor-stroma interface at the cellular and tissue levels, enabling assessment of glycolytic and inflammatory tumor properties in relation to histological features. This data-driven, systems biology approach will integrate transcription, signaling, and metabolic network models with cellular microscopy, 3D tissue imaging, and PET/CT imaging data. The goal is to establish more definitive PDAC phenotypes that are consistent across multiple spatial scales, leading to a non-invasive imaging test for PDAC phenotyping and new potential cellular targets for treatment.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $623.0k | 7/12/24 |