This Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) aims to advance a local controlled release platform for intratumoral delivery of hyaluronidase to improve the efficacy of systemically administered drugs for pancreatic ductal adenocarcinomas (PDAC). The award totals $599,474 and will fund a 5-year project from Sep 1, 2024 to Aug 31, 2029. The key products and services to be delivered through this grant include: 1) using multi-scale modeling to define the parameter space for implant design to achieve uniform distribution of hyaluronidase within PDAC tumors, 2) using medical imaging to characterize the effects of stromal targeting agents on tumor blood flow and drug accumulation, and 3) evaluating the immunomodulatory effects and treatment efficacy of stromal targeting therapies. The goal is to establish a novel approach for targeting PDAC tumor desmoplasia, improving mass transport into tumors, and enhancing immune cell infiltration. The award recipient is Purdue University, a prominent public research institution with extensive experience executing federal grants and contracts.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $599.5k | 8/30/24 |