Project Grant R01AI184531

Award Date 3/25/25
Completion Date 2/28/30
Dollars Obligated $751K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Baltimore, MD 21201, USA
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This federal Project Grant award of $750,815, provided by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research), supports research to develop novel anti-infective strategies for treating pulmonary mucormycosis, a deadly invasive fungal infection.

The project aims to examine the role of the host cell hypoxia-response pathway in mucormycosis pathogenesis and explore the therapeutic potential of targeting key downstream effectors like ANGPTL4. The research also involves using single cell RNA-sequencing to identify transcriptional targets of this pathway that are expressed during infection, and evaluating the effectiveness of these targets as adjunctive therapy with antifungal agents in clinically relevant mouse models. The ultimate goal is to disrupt molecular interactions critical for disease progression of pulmonary mucormycosis, an infection with limited treatment options and extremely high mortality rates.

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