Project Grant R35NS143059

This Project Grant award of $1,271,040.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) supports innovative research at Rockefeller University aimed at discovering new therapeutic targets for neurological diseases. The key products and services to be delivered include:

1. Developing and validating new model systems to enable unexpected discoveries about the fundamental mechanisms underlying neurological disorders. This will involve integrating data from model systems with a novel approach to study molecular variations in neurons obtained from human autopsy samples.

2. Applying advanced techniques, such as CLIP (cross-linking immunoprecipitation), to map RNA regulation in single neuronal cell types, subcellular domains, and during neuronal depolarization. This will provide insights into how genetic (DNA) etiologies manifest in downstream RNA and protein changes contributing to brain diseases.

3. Conducting computational biology analyses of complex molecular datasets to identify actionable subsets of regulatory mechanisms and therapeutic targets for neurological conditions. The goal is to bridge the gap between model systems and human neurobiology to develop new treatment strategies.

The award period runs from May 1, 2025 to April 30, 2033, aiming to deliver transformative discoveries in the fundamental understanding and potential treatment of neurological diseases.