Project Grant R35NS137312

Award Date 12/15/24
Completion Date 11/30/32
Dollars Obligated $1.3M
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
California, USA
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This Project Grant award of $1,341,874 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research on dendrite development, function, degeneration, and regeneration. The primary focus areas include:

  1. Elucidating the molecular mechanisms controlling dendrite development, particularly the "tiling signal" that mediates mutual repulsion between adjacent dendrites. This research leverages Drosophila genetics and cell surface proteome analysis techniques.

  2. Studying the mechano-sensation exhibited by Drosophila dendritic arborization neurons, including the gating mechanism of the NOMPC channel and the physiological function of mechano-sensitive channels like DOSCA.

  3. Uncovering the mechanisms underlying dendrite and axon regeneration after injury, exploring factors that can enhance or inhibit regeneration using the Drosophila dendritic arborization neuron system.

The ultimate goal is to advance the fundamental understanding of neuroscience and provide insights that could contribute to potential future treatments for neurological disorders associated with dendrite defects, such as Down's syndrome and autism spectrum disorder. The award period runs from December 2024 through November 2032 and is being carried out by the University of California, San Francisco.

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