This federal Project Grant award for $1,174,913 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA Program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders supports research on homeostatic plasticity, a compensatory process that stabilizes neural function. The grantee, The Regents of the University of California, San Francisco (UCSF), will use genome-scale forward genetic screens in Drosophila to discover fundamental mechanisms of presynaptic homeostatic plasticity (PHP), a potent form of homeostatic plasticity. The identified mechanisms will then be translated and tested for conservation of function in mouse neuromuscular junction and adult hippocampal preparations, with the goal of determining their intersection with the pathophysiology of neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The project aims to identify positive genetic modulators of PHP to promote homeostatic plasticity and enhance neurological resilience to disease.
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