Project Grant R35HL184262
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of California, San Francisco a $556,295 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) effective August 1, 2025, with completion scheduled for May 31, 2030. This award supports research to advance understanding of cardiac pacemaking physiology and sinus node dysfunction (SND) through investigation of specialized pacemaker cell subpopulations. The...
- Federal Grant Award Summary The University of Arizona received a $1,476,174 Project Grant from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through May 31, 2029. The award funds basic research investigating the role of hepatocyte transmembrane protein 141 (TMEM141) in lipoprotein metabolism and atherosclerosis development. The project delivers scientific research outputs through the use of genetically...
- Grant Award Summary The University of Arizona received a $1.57 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 5, 2026, with completion scheduled for February 28, 2028. The award funds research on ATF6 (Activating Transcription Factor 6) as a regulator of endoplasmic reticulum (ER) proteostasis in atrial myocytes. The project investigates how ATF6, an ER-localized transcription...
- Summary of Federal Project Grant Award The University of Texas Southwestern Medical Center received a $498,000 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 2, 2025, with completion scheduled for August 31, 2028. The award funds investigative research into the molecular determinants of atrial fibrillation (AF), a condition affecting an estimated 33.5 million individuals globally with...
- Grant Award Summary The University of Arizona received a $576,786 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 5, 2025, with completion targeted for August 31, 2028. This research initiative investigates protein translation mechanisms underlying oxidative stress response in heart failure, specifically examining the role of YTHD2 (a YTH domain-containing N6-methyladenosine binding...
- Federal Project Grant Summary The University of Arizona received a $140,400 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026 through June 30, 2031. The grant funds "Corazón en Tus Manos," a culturally-tailored cardiovascular disease (CVD) risk-reduction intervention designed specifically for Mexican-origin adults with confirmed metabolic dysfunction-associated...
- Federal Grant Award Summary The University of California, San Francisco received a $169,120 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on July 28, 2025, with completion targeted for March 31, 2030. This research project investigates the role of SYNE1-GIANT protein in atrial cardiomyopathy, focusing on understanding how mechanosensitive molecules at the nuclear envelope contribute to atrial...
- Federal Project Grant Award Summary The University of Texas Southwestern Medical Center received a $608,173 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026, with completion targeted for March 31, 2031. This research grant funds an investigator-initiated biomedical research project examining the role of the stretch-activated PIEZO1 ion channel in the pathophysiology of heart...
- Federal Project Grant Award Summary Arizona State University received a $252,676 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for August 31, 2027. The award funds development and evaluation of the Computer Aided Exercise Stress ECG Reader (CAESAR), an artificial intelligence-driven diagnostic tool designed to improve the accuracy of exercise stress...
- Federal Grant Award Summary Northwestern University received a $601,612 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through June 30, 2029. The award supports the development of an epicardial high-definition electrotherapy system for treatment of paroxysmal atrial fibrillation (AFib). The project will develop a fully implantable, organ-conformal device incorporating...
The University of Arizona, operating as the Arizona Board of Regents, received a Project Grant award of $558,127 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2026 through July 31, 2033. The project, titled "Decoding the Enigma of Cardiac Arrhythmia and Mechanosensitivity," will deliver multidisciplinary research aimed at understanding small conductance calcium-activated potassium (SK) channels in the heart, with particular focus on their role in atrial fibrillation and heart failure pathology. The funded research will combine experimental and computational studies across four collaborating laboratories to investigate SK channel remodeling in diseased hearts. Deliverables include structural and functional characterization of SK channels, optogenetic tool development for channel analysis, and computational modeling to explain the mechanisms underlying SK channel upregulation in heart failure and their dual role (both anti-arrhythmic and pro-arrhythmic) in various cardiac disease models. This work addresses critical knowledge gaps necessary to evaluate SK channel inhibitors as potential therapeutic targets for cardiac arrhythmias and advance understanding of repolarization reserve mechanisms in failing hearts.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $558.1k | 7/3/26 |