Project Grant R35HL184260
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $678,710 to Henry Ford Health + Michigan State University Health Sciences on June 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate a novel multi-sensor machine learning (ML) approach for precision sleep tracking in nightshift workers. The project, which extends through April 30, 2030, addresses a critical public health gap by creating ML algorithms...
- Federal Grant Award Summary Brigham & Women's Hospital Inc. received a $3.24 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on September 23, 2025, with completion by June 30, 2027. This research project investigates the role of ambient lighting in circadian misalignment and cognitive dysfunction among individuals experiencing chronic variable sleep deficiency (CVSD). The research...
- Federal Grant Award Summary Brigham & Women's Hospital Inc. received a $563,120 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with a completion date of August 31, 2027. The award funds mathematical modeling research focused on peripheral metabolic circadian rhythms and their implications for managing circadian disruption associated with shift work and jet lag. The...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $721,041 through the Cardiovascular Diseases Research program (CFDA 93.837) to The Research Foundation for the State University of New York on June 5, 2025, for a project examining the role of cardiac circadian clock misalignment in promoting arrhythmias. The research will be conducted through March 31, 2030, at facilities in New York and will investigate the mechanisms by which chronic ischemia creates...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $743,388 to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate mechanisms by which sleep loss and circadian misalignment induce insulin resistance. The research will establish the relationship between cortisol rhythm patterns and timing with insulin resistance...
- Federal Grant Award Summary Brigham and Women's Hospital Inc. received a $177,385 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 20, 2025, with an ultimate completion date of August 31, 2030. The project investigates place-based factors contributing to sleep health disparities (SHD) in the United States, addressing a gap identified in the NIH 2021 Sleep Research Plan regarding...
- Federal Grant Award Summary The University of Michigan received a $619,882 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) effective July 5, 2025, with completion targeted for April 30, 2030. The grant funds a mechanistic clinical trial designed to personalize heart failure treatment through genomic analysis. The research will prospectively validate a polygenic risk score (PRS) for predicting...
- Federal Project Grant Award Summary Michigan Technological University received a $589,998 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2028. The award funds research investigating cardiac sensory and sympathetic nerve dysregulation in hypertrophic cardiomyopathy (HCM), a genetic heart disease affecting approximately 1 in 500 individuals and representing...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of California, Irvine a Project Grant of $1,296,660 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 25, 2025, to conduct research elucidating the mechanistic pathways linking obstructive sleep apnea (OSA) and cardiovascular disease (CVD). The research employs an integrated "bed to bench" approach combining clinical, computational, and laboratory...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to investigate the relationship between circadian disruption and cardiometabolic risk during the transition from adolescence to young adulthood. The $691,124 award to the Regents of the University of Michigan will leverage existing data on sleep/wake patterns and cardiometabolic health biomarkers to test the hypothesis that persistent circadian disruption is linked to...
The National Heart, Lung, and Blood Institute (NHLBI) awarded $1,099,000 under the Cardiovascular Diseases Research program (CFDA 93.837) to Michigan State University/Henry Ford Health+ on June 1, 2026, for a project titled "Precision Circadian Medicine for Shift Workers in the Digital Era." The project, which extends through March 31, 2033, will develop and scale precision circadian medicine solutions for the approximately 20% of the workforce engaged in essential nightshift operations (first responders, hospital workers, nuclear facility operators). The primary deliverable is a multi-level, evidence-based framework transforming shift work disorder (SWD) assessment from a unidimensional to a socioecological construct, leveraging consumer-based wearable technology and digital health platforms. Building upon Dr. Cheng's prior NIH-funded foundational work—including creation of an open-source, free web portal for tracking circadian rhythms via wearable technology—this project will establish optimal light therapy dosing protocols for therapeutic response and deliver actionable precision medicine recommendations. The initiative directly addresses catastrophic safety consequences of impaired performance in safety-sensitive industries by providing evidence-based interventions that account for circadian misalignment, socioeconomic factors, and individual physiological variation. Collaboration with national leaders in sleep and circadian medicine research will generate peer-reviewed publications, refined clinical protocols, and scalable digital health tools for implementation across essential service sectors.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 3/19/26 |