Project Grant R35GM166481
- The National Institute of General Medical Sciences (NIGMS) at the Department of Health and Human Services awarded $420,093 to the Regents of the University of Michigan on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds a five-year investigation into how cells self-organize to sculpt tissue interfaces and generate the characteristic curvatures that shape organ architecture and function. The research takes a systems-level approach to...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $400,881 on February 26, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to uncover principles of tissue morphogenesis through data science and machine learning approaches. The research centers on modularity in tissue formation—the concept that cells rely on a finite set of reusable behaviors such as division, migration, and shape change to build diverse tissue...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $426,539 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop AI-driven robotic systems that plan, execute, and interpret automated experiments mapping bacterial pathogen phenotypes and quorum sensing pathways. The work focuses on context-specific cellular networks in streptococci, integrating metabolism and quorum sensing into a quantitative...
- The National Institute of General Medical Sciences awarded Michigan State University $294,266 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop mathematical and computational models that reconstruct high-resolution three-dimensional spatial genome architectures across diverse biological contexts. The project addresses the critical limitation that three-dimensional DNA folding configurations vary substantially across different cell types,...
- The National Institute of General Medical Sciences awarded $419,823 to Regents of the University of Michigan on August 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to establish a predictive science of adsorption-limited drug transport across complex biological tissues. The research addresses saturable adsorption to tissue matrices—a hidden barrier that prevents potent therapeutics from reaching their targets in airway mucus, biofilms, granulomas, and tumors....
- The National Institute of General Medical Sciences awarded $565,993 to Regents of the University of Michigan on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation native ion mobility-mass spectrometry (NIM-MS) methods for characterizing biotherapeutics, including protein and nucleic acid therapeutics. The project focuses on creating rapid, droplet-based enzymatic chemistries and collision-induced unfolding (CIU) approaches to assess...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $425,916 under the Biomedical Research and Research Training program (CFDA 93.859) on June 1, 2026. The award funds a five-year investigation into the mechanisms of lysosomal resilience, repair, and removal. Research will examine how cells sense acute changes in lysosomal membrane structure and coordinate restorative responses, including how local membrane remodeling and reinforcement by ESCRT...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $473,238 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, for development of CARTOSCOPE, an integrated cloud platform for processing, visualizing, and sharing micron-scale spatial omics data. The platform addresses advances in single-cell and spatial multi-omics technologies that enable molecular profiling of individual cells and spatially resolved...
- The National Institute of General Medical Sciences awarded Regents of the University of Michigan $429,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to map mobile-element insertions and repeat expansions across human tissues and develop diagnostic tools. The project couples CRISPR-guided DNA enrichment, ultra-long nanopore sequencing, and advanced computational modeling to create a comprehensive map of transposable-element insertions and short...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the Regents of the University of Michigan $427,615 on August 1, 2026, to investigate how intrinsically disordered regions in proteins affect the search and binding of heterochromatin-associated proteins in living cells. This Project Grant under the Biological Sciences program (CFDA 47.074) funds collaborative research examining how histone H3 lysine 9 methylation-binding proteins dynamically recruit and retain...
The National Institute of General Medical Sciences awarded $410,473 to the Regents of the University of Michigan on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop quantitative theory and computational models of collective cellular response to complex biophysical cues. The research encompasses two projects: investigation of swarming bacterial colonies' response to intestinal tissue cues in healthy and disease states, and analysis of self-organized morphogenesis and patterning during zebrafish embryonic gastrulation, integrating tissue mechanics with gene expression patterns and germ layer induction. Work is performed in Ann Arbor, Michigan, with a period of performance from August 1, 2026, through April 30, 2031. Models will be built by identifying collective variables describing coarse-grained system dynamics and will be integrated with quantitative experimental data from collaborators, aiming to uncover biophysical mechanisms enabling group-level cellular response underlying physiological function and robust patterning in multicellular systems.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $410.5k | 7/24/26 |