Project Grant R01GM166173
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $400,881 on February 26, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to uncover principles of tissue morphogenesis through data science and machine learning approaches. The research centers on modularity in tissue formation—the concept that cells rely on a finite set of reusable behaviors such as division, migration, and shape change to build diverse tissue...
- The National Institute of General Medical Sciences awarded Regents of the University of Michigan $429,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to map mobile-element insertions and repeat expansions across human tissues and develop diagnostic tools. The project couples CRISPR-guided DNA enrichment, ultra-long nanopore sequencing, and advanced computational modeling to create a comprehensive map of transposable-element insertions and short...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $378,252 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop virtual educational resources and training models in data visualization for biomedical researchers. The award funds creation of two complementary educational offerings. The first will generate resources enabling researchers to conduct constructive critiques of existing data...
- The National Institutes of Health Office of the Director awarded the Regents of the University of Michigan $430,143 on June 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to purchase an OCTET-RH16 system employing bio-layer interferometry technology for the Center for Structural Biology at the Life Sciences Institute. The system will measure the kinetics of biomolecular interactions—association rates (KA), dissociation rates (KD), and affinity constants—in...
- The National Institute of General Medical Sciences awarded $410,473 to the Regents of the University of Michigan on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop quantitative theory and computational models of collective cellular response to complex biophysical cues. The research encompasses two projects: investigation of swarming bacterial colonies' response to intestinal tissue cues in healthy and disease states, and analysis of...
- The National Institute of General Medical Sciences (NIGMS) at the Department of Health and Human Services awarded $420,093 to the Regents of the University of Michigan on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds a five-year investigation into how cells self-organize to sculpt tissue interfaces and generate the characteristic curvatures that shape organ architecture and function. The research takes a systems-level approach to...
- The National Institute of General Medical Sciences awarded $565,993 to Regents of the University of Michigan on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation native ion mobility-mass spectrometry (NIM-MS) methods for characterizing biotherapeutics, including protein and nucleic acid therapeutics. The project focuses on creating rapid, droplet-based enzymatic chemistries and collision-induced unfolding (CIU) approaches to assess...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $426,539 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop AI-driven robotic systems that plan, execute, and interpret automated experiments mapping bacterial pathogen phenotypes and quorum sensing pathways. The work focuses on context-specific cellular networks in streptococci, integrating metabolism and quorum sensing into a quantitative...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $425,916 under the Biomedical Research and Research Training program (CFDA 93.859) on June 1, 2026. The award funds a five-year investigation into the mechanisms of lysosomal resilience, repair, and removal. Research will examine how cells sense acute changes in lysosomal membrane structure and coordinate restorative responses, including how local membrane remodeling and reinforcement by ESCRT...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $411,475 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to engineer a multiplexed biomaterial-based bioluminescent biosensor platform for real-time sepsis diagnosis and precision immunotherapy guidance. The recipient will develop a rapid ex vivo biosensor using biomaterial-immobilized complementation antibody pairs to dynamically sense proteomic...
The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $473,238 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, for development of CARTOSCOPE, an integrated cloud platform for processing, visualizing, and sharing micron-scale spatial omics data. The platform addresses advances in single-cell and spatial multi-omics technologies that enable molecular profiling of individual cells and spatially resolved transcriptome analysis at submicron resolution across solid tissues, including cancer lesions, using outputs from spatial transcriptomics instruments including VIZGEN MERSCOPE, 10X Xenium, Visium HD, COSMX SMI, SEQ-SCOPE, OPENST, NOVA-ST, BGI STEREO-SEQ, Singular G4X, and Illumina Spatial Platform. Work is performed at the University of Michigan in Ann Arbor, Michigan, with a period of performance from September 1, 2026, through August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $473.2k | 8/11/26 |