Project Grant R35GM166440
- The National Institute of General Medical Sciences, part of the National Institutes of Health under the Department of Health and Human Services, awarded The Leland Stanford Junior University $152,600 on December 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms underlying constitutive heterochromatin formation at human centromeres. The project will determine how non-catalytic domains of the histone methyltransferase SETDB1 maintain...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $385,000 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the three-dimensional folding of the human genome in single cells. The research will develop systematic, large-scale genetic and chemical perturbation screens paired with single-cell whole-genome 3D structure and transcriptome measurement to identify the physical and chemical...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $236,736 on August 9, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemically induced proximity methodology for rewiring nucleosome engagement patterns. The project runs through April 30, 2028, with work performed in Palo Alto, California. The funded research applies bivalent molecules that bind and bring together two biomolecules to promote the...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $1.924 million on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how nuclear mechanical properties regulate cell functions independently of gene expression. The research examines whether and how mechanical properties of the nucleus—including size, stiffness, and integrity—control essential cellular processes such as migration, proliferation,...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $152,600 on December 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support molecular dissection of CMG helicase assembly in metazoa. The research uses single-molecule imaging to determine how CDC45 is loaded onto DNA replication origins in metazoan cells. The investigator will employ real-time tracking in Xenopus laevis nuclear extracts to determine whether...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $304,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply adaptive optical tweezers for probing live cell membrane tension dynamics in health and disease states. The funded research focuses on quantifying physical forces and mechanical properties governing cellular processes, particularly cell membrane tension during mitosis. The...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded The Leland Stanford Junior University $1 million on July 1, 2026, under the Biological Sciences program (CFDA 47.074) to investigate how enhancer networks control gene expression through chromosomal organization and dynamics. The research integrates genomic perturbation using CRISPR technology, live-cell fluorescent imaging to observe DNA movement in real time, and computational modeling combining...
- The National Institutes of Health National Human Genome Research Institute awarded The Leland Stanford Junior University $721,450 on March 1, 2026, under the Human Genome Research program (CFDA 93.172) to develop genome-wide maps of enhancer-gene regulatory interactions and link noncoding variants to disease-associated target genes. The project extends computational and experimental tools to map enhancer-gene regulatory interactions using single-cell multiomic datasets across hundreds of human...
- The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University $125,000 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the molecular organization and function of oocyte spindles. The funded research addresses age-related fertility decline and aneuploidy in human embryos by investigating how oocytes assemble functional spindles without centrosomes—termed acentrosomal meiosis—and how tubulin...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $616,000 on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation proximity labeling enzymes for mapping spatial proteomes in living cells. The research aims to engineer and optimize FLEXID and LACCID, two proximity labeling enzymes designed to overcome limitations of existing methods like APEX and TURBOID in specificity, sensitivity, and...
The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $423,500 on September 1, 2026, to apply novel genomic tools to study centromere organization, replication, and function under the Biomedical Research and Research Training program (CFDA 93.859). The funded work generates complete satellite DNA annotations for a gapless, diploid human reference assembly using long-read sequencing and genome assembly advances. The recipient employs dimelo-seq, a long-read protein-DNA interaction mapping method previously developed, to map centromere-associated proteins including centromere protein A (CENP-A) along single chromatin fibers at their exact locations within each human centromere. This approach reveals fine-scale associations between endogenous DNA methylation, centromere protein localization, and repetitive DNA sequences. The research tests the hypothesis that localized DNA hypomethylation restricts CENP-A positioning and promotes epigenetic transmission of centromere identity through dimelo-seq and engineered genetic perturbation experiments. Future work refines dimelo-seq to quantitatively map CENP-A and other proteins at single-nucleosome resolution throughout the cell cycle. Period of performance runs from September 1, 2026, through August 31, 2031. Work is performed in Palo Alto, California. This is a Project Grant, the standard assistance type for investigator-initiated biomedical research under NIGMS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 8/31/26 |