Project Grant R35GM166435
- The National Institute of General Medical Sciences awarded Purdue University $303,804 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a correlative and multimodal molecular imaging platform for spatially-resolved analysis of biomolecules in biological tissues. The project focuses on advancing nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI), an ambient ionization technique that enables highly...
- Federal Project Grant Award Summary The University of Arkansas received a $562,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2028. This award supports fundamental research investigating lysine aminoacylation, an emerging post-translational protein modification observed in human metabolic enzymes. The project will advance understanding of...
- The National Institute of General Medical Sciences awarded the University of Illinois $113,211 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop mass spectrometry-based instrumentation and computational tools for spatiotemporal neuropeptidomics with isomer-resolved capabilities. The work will map neuropeptide distribution and release with high spatial and temporal resolution and increased throughput, creating new molecular signatures of...
- The National Institute of General Medical Sciences awarded the University of Missouri System $2.285 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop artificial intelligence methods for reconstructing protein complex structures from cryo-electron microscopy data and predicting mutated protein structures. The award funds research to address two key gaps in structural bioinformatics: the lack of automated, accurate methods for...
- Federal Project Grant Award Summary Arizona State University received a $1,977,264 Project Grant award, effective September 15, 2025, through August 31, 2029, under the National Institute of General Medical Sciences' Biomedical Research and Research Training program (CFDA 93.859). The award funds development of a novel multimodal imaging platform that integrates fluorescence super-resolution and tomographic polarized light imaging technologies to enable cellular and unicellular organism...
- The National Institute of General Medical Sciences awarded the University of Illinois $380,350 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to systematically characterize human disease-associated protein complexes. The recipient will develop machine learning approaches to identify biologically relevant protein complex variants from over 32,000 mass spectrometry experiments, construct cell-type-specific protein complex maps focusing on early embryonic...
- The National Institute of General Medical Sciences awarded the University of Florida $1,892,969 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel mass spectrometry technologies for high-resolution molecular imaging of tissue samples. The research addresses critical deficiencies in imaging mass spectrometry (IMS) by advancing chemistries and next-generation analytical techniques that improve both chemical differentiation and spatial...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop IMAGE-SEQ, a platform integrating high-resolution in vivo optical imaging with spatially resolved single-cell transcriptomics. The award funds three major expansions of the technology: integration with single-cell proteomics to capture protein-level signaling events and define how proliferative...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $133,515 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a multi-omic mass spectrometry imaging platform for visualizing inflammatory disease biomarkers in tissue sections. The funded work addresses technical limitations in current matrix-assisted laser desorption/ionization mass spectrometry imaging approaches by developing optimized protocols and...
- The National Institute of General Medical Sciences awarded Arizona State University $2,081,661 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop plasmonic and evanescent scattering microscopy technologies for label-free functional imaging of single molecular and cellular activities. The recipient will advance optical detection methods that measure intrinsic molecular and cellular optical properties without fluorescent or radioactive...
The National Institute of General Medical Sciences awarded the University of Arkansas $400,499 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop SIMUL-Proteomics, a next-generation spatial proteomics platform enabling simultaneous multiplexed imaging at single-protein resolution. The platform integrates spectral phasor analysis, spectrally engineered probes including quantum dots, and light sheet illumination to overcome limitations of existing single-molecule localization microscopy methods such as DNA-PAINT. SIMUL-Proteomics eliminates sequential readout requirements, minimizes sample perturbation, and improves acquisition speed by more than 100-fold compared to current approaches, enabling up to 60-plexed imaging. The technology will deliver quantitative nanoscale mapping of protein distributions and interactions in cells, tissues, and small organisms in a single imaging round, advancing understanding of protein organization and assembly at molecular scales where existing mass spectrometry and imaging-based proteomics methods are limited. The award funds research at the University of Arkansas, Fayetteville through June 30, 2031. This is a Project Grant, an assistance type supporting investigator-initiated biomedical research under NIGMS's mission to increase understanding of biological processes and lay the foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.5k | 8/31/26 |