Project Grant R35GM166382
- The National Institute of General Medical Sciences awarded $406,250 to the University of Pennsylvania on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop statistical and computational methods for analyzing complex multimodal biological datasets. The recipient will develop correlated latent factor models to extend multi-omic inference capabilities across complex study designs, including model-based imputation methods for handling missing data...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $924,095 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms controlling actin cytoskeleton dynamics. The research addresses four major knowledge gaps: the ARP2/3 complex's role in actin filament branching and regulation by nucleotide state and binding proteins; filament dynamics at barbed and pointed ends, including cooperative...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $665,172 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the structure, mechanism, and inhibition of metal-dependent enzymes. The research explores histone deacetylases (HDACs) 6, 10, and 11 as targets for drug design in cancer chemotherapy, immune modulation, and neurodegenerative disease treatment, including development...
- The National Institute of General Medical Sciences awarded $2,373,884 to the University of Pennsylvania on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a scalable, multimodal framework for modeling and predicting complex disease interactions using electronic health records and biobank data. The research program constructs disease-disease networks—graph-based models capturing shared genetic, molecular, and clinical relationships across...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $487,287 on March 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support investigation of circadian rhythm mechanisms beyond traditional genetic control. The research explores how cells and organisms maintain daily temporal organization through integration of genetic and non-genetic mechanisms, with focus on metabolic and redox processes that sustain...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $881,151 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural, biochemical, and biophysical properties of cytoskeletal motor proteins, specifically myosin paralogs and their interactions with regulatory partners and actin dynamics. Research activities include structural studies to explore force generation, regulation,...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on membrane remodeling by membrane-bound motors. The project investigates how class I myosin (myosin-I) couples actin filaments to lipid membranes at the actin-membrane interface, bridging a gap in understanding how cells coordinate mechanical forces and membrane...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $688,506 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct integrative genomic analyses of human evolution and complex traits in African populations. The research applies an integrative evolutionary genomics approach incorporating genomic, metabolomic, proteomic, microbiome, epigenomic, and transcriptomic data combined with detailed...
- The National Institute of General Medical Sciences awarded the University of Texas at Dallas $1.928 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for a project grant investigating how cellular metabolism shapes embryonic development. The funded research integrates advanced imaging, genetic tools, and single-cell sequencing in the chordate model Ciona to examine how metabolic rewiring orchestrates gene regulatory networks during...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $460,771 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct basic research on the molecular mechanisms regulating zygotic genome activation during early embryonic development. The research addresses the transition from maternal to zygotic transcriptional control following fertilization, focusing on how pioneer transcription factors in the...
The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $424,513 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for systems biology research into metabolic support of cell proliferation. The award is a Project Grant under the MIRA (Maximizing Investigators' Research Award) authority. The funded research applies systems biology approaches to develop a holistic understanding of how cells coordinate thousands of metabolic reactions to achieve proliferation across different cell types, nutrient conditions, and tissue microenvironments. The first objective is to computationally reconstruct a compact and precise genome-scale metabolic model capable of predicting cellular response to metabolic perturbations in different cell types. The work addresses fundamental challenges in mammalian cell metabolism, including multiple layers of redundancy that ensure robustness and the highly interconnected nature of metabolic networks through shared substrates, products, and cofactors. Performance occurs at the University of Pennsylvania in Philadelphia, Pennsylvania, with a period of performance ending March 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $424.5k | 8/13/26 |