Project Grant R35GM166183
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $441,375 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanobiology in tissue-mimetic contexts. The recipient's research addresses how cells sense, process, and respond to mechanical signals within their microenvironment, with focus on the viscoelastic properties of the...
- The National Institute of General Medical Sciences (NIGMS) of the Department of Health and Human Services awarded the University of California, Berkeley $287,221 in project grant funding on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into the molecular dynamics of biomolecules and their interactions, with emphasis on fusing biophysics and machine learning approaches. The work develops rigorous computational models and...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $246,263 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into post-transcriptional regulatory networks and the integrated stress response (ISR). The work will comprehensively characterize the cofactors engaged by regulatory RNA-binding proteins and...
- The National Institute of General Medical Sciences awarded the University of California, Berkeley $329,491 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, to elucidate the molecular basis of necroptosis through a five-year project extending to May 31, 2031. The funded research investigates the ZBP1-RIPK3-MLKL necroptosis pathway, specifically how ZBP1 transitions from inactive to assembled states to engage RIPK3, how MLKL undergoes conformational...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $233,283 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how tissue environment shapes neutrophil cell death fate and function. The research integrates live tissue imaging, spatial transcriptomics, chromatin profiling, and genetic models to define the fundamental rules governing whether neutrophils undergo netosis, apoptosis, or...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded the University of California, Davis $1.624736 million under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026. The award funds research into morphological reprogramming of the endoplasmic reticulum by cellular mucins. The project tests the hypothesis that transmembrane mucins act as membrane curvature generators on the luminal face of the endoplasmic...
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of Allergy and Infectious Diseases awarded $787,945 to the Regents of the University of California, doing business as University of California, Berkeley, on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research defines the specificity requirements and functional properties of regulatory T cells (Tregs) that maintain tolerance to the microbiota, with emphasis on RORγt+ Tregs generated during the peri-weaning period in mice...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $2.255 million under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026. The award funds development, application, and dissemination of integrative structure modeling methods for computing structural and spatiotemporal models of biomolecular complexes. The recipient will expand the scope of the open-source Integrative Modeling Platform...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $551,000 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop function-selective modulators of multifunctional hub proteins. The research expands two programs: developing molecular glues to stabilize native protein-protein interactions and establishing technologies to study dynamic protein-interaction networks. The work...
The National Institute of General Medical Sciences awarded $441,375 to The Regents of the University of California, doing business as University of California, Berkeley, on September 1, 2026, under the R35 (MIRA) program (CFDA 93.859, Biomedical Research and Research Training). The award funds a five-year project investigating how tissues integrate immune-cell derived signals to regulate inflammation, repair, and homeostasis. The research pursues three interconnected directions: dissecting how cytokine-induced STAT1 and STAT3 signaling reshapes epithelial barrier states across skin, gut, and lung; mapping shared cytokine signaling nodes that sustain pathogenic fibroblast states in arthritis and fibrosis models; and engineering epithelial- and fibroblast-targeted cytokine ligands capable of shifting disease-relevant tissue states in vivo. The work integrates cytokine biology, protein engineering, and in vivo models to both decode the rules governing inflammatory tissue states and design tools to reprogram them, with the goal of establishing a generalizable framework for precise reprogramming of pathogenic tissue states in chronic inflammation. Performance occurs at UC Berkeley, Berkeley, California. The period of performance runs from September 1, 2026, through May 31, 2031. The award is classified as a Project Grant under the MIRA (Maximizing Investigators' Research Award) program, which NIGMS generally prioritizes over R01 awards to support meritorious investigators.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $441.4k | 8/28/26 |