Project Grant R35GM166091
- The National Institute of General Medical Sciences awarded the University of Florida $386,985 on July 23, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct a five-year investigation into the structure-function relationships of single-stranded DNA (ssDNA) in biological systems. The research will develop methods to probe structured ssDNA in cells, with initial focus on two biomedically relevant lines of investigation. The first examines complex ssDNA...
- The National Institute of General Medical Sciences awarded Duke University $523,255 on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the mechanisms, regulation, and impact of transposon activation through the Project Grant mechanism (R35GM161651). The award funds fundamental research investigating how transposons—elements comprising nearly 50% of the human genome—are regulated and how they contribute to genome stability and...
- The National Institute of General Medical Sciences, National Institutes of Health, awarded the University of Florida $422,125 on August 15, 2026, to develop rapid, wash-free fluorescent signal-switching methods for high-plex RNA imaging in cells and tissues under the Biomedical Research and Research Training program (CFDA 93.859). The research addresses limitations in current multiplexed fluorescence imaging by establishing a DNA displacement reaction-based signal exchange (DIRSE) platform...
- The National Institute of General Medical Sciences awarded the University of Florida $383,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct basic research on post-translational modification systems in archaea, with performance through January 31, 2031, at Gainesville, Florida. The project advances understanding of how post-translational modifications coordinate to regulate stress response in the archaeon Haloferax volcanii. Three...
- The National Institute of General Medical Sciences awarded the University of Florida $422,125 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of schlafen-mediated phage defense. The award funds two projects examining how schlafen nucleases function as an ancient antiviral defense mechanism. Project 1 determines the molecular, structural, and biochemical basis of schlafen immunity in bacterial systems. Project...
- The National Institute of General Medical Sciences awarded the University of Florida $114,100 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support basic research on the functional dynamics and regulatory mechanisms of RAD3/XPD-family helicases during DNA replication stress. The research investigates how helicases are modulated by protein-protein interactions to maintain replication fork integrity when cells encounter DNA lesions and...
- The National Institute of General Medical Sciences awarded the University of Florida $1,892,969 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel mass spectrometry technologies for high-resolution molecular imaging of tissue samples. The research addresses critical deficiencies in imaging mass spectrometry (IMS) by advancing chemistries and next-generation analytical techniques that improve both chemical differentiation and spatial...
- The National Institute of General Medical Sciences awarded the University of South Florida $474,102 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct synthetic biology and genome engineering of polyketide natural products, develop bioactive metabolites from Antarctic marine invertebrates and deep-sea organisms, synthesize chemical analogs to modulate toxicity and enhance drug-like properties, and advance compound development initiatives...
- The National Institute of General Medical Sciences awarded Florida International University $405,625 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the functional dynamics, membrane orientation, and complex organization of cytochrome P450 aromatase (CYP19) and its interactions with cytochrome P450 reductase (CPR). The research integrates classical biophysical techniques with advanced tools including synchrotron X-ray footprinting mass...
- The National Institute of General Medical Sciences awarded Cornell University $424,158 on July 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of the Kumgang/MI-2 chromatin remodeling complex and its role in transcriptional fidelity. The research will characterize how tissue-specific zinc finger proteins (ZFPs) interact with the chromatin remodeler MI-2 to repress inappropriate gene transcription. The project will...
The National Institute of General Medical Sciences awarded the University of Florida $398,545 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how active and silenced transposable elements shape meiotic recombination in maize and rice. The research will generate high-resolution crossover maps and perform genome-wide assessment of recombination frequency near transposon insertions, examine whether transposon-derived double-strand breaks introduce crossovers, and determine how transposon excision or insertion alters chromatin structure, chromatin accessibility, and three-dimensional genome organization at insertion sites and flanking regions. The work addresses how active Mutator transposons in maize and silenced transposable elements influence recombination by affecting crossover interference, the synaptonemal complex, double-strand break repair, and chromatin structure. Work is performed in Gainesville, Florida with a period of performance extending from September 3, 2026, through April 30, 2031. The University of Florida Division of Sponsored Research administers the award as the prime recipient.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $398.5k | 9/3/26 |