Project Grant R35GM166012
- The National Institute of General Medical Sciences awarded the University of Utah $556,000 on August 25, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance precise genome editing methods in zebrafish. The award funds development and optimization of a base-substitution editing technique using single-strand DNA donors and a nickase version of Cas9 (Cas9D10A) to direct homology-directed repair. The funded work will improve editing efficiency, establish and...
- The National Institute of General Medical Sciences, operating as part of the Department of Health and Human Services National Institutes of Health, awarded the University of Utah $423,500 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research investigating the biological functions, biosynthesis, and dynamic regulations of RNA chemical modifications. The research program addresses three key challenges: identifying proteins that...
- The National Institute of General Medical Sciences awarded the University of Utah $885,637 in project grant funding on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The University of Utah, through its Office of Sponsored Projects Division, will conduct a five-year investigation into the molecular and metabolic adaptations that enable apicomplexan parasites—particularly Plasmodium species that cause malaria—to survive and replicate within host cells....
- The National Institute of General Medical Sciences awarded the University of Utah $392,942 on May 22, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the regulation of single-cell migration in vivo. The award funds investigation into how focal adhesion structures form and function during cell migration in living organisms, specifically using zebrafish larval skin as a model system to directly visualize focal adhesion dynamics in highly...
- The National Institute of General Medical Sciences awarded The Regents of the University of California (UC Riverside) $420,520 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct mechanistic studies of CRISPR-Cas9 genome editing using molecular simulations and AI-driven approaches. The research integrates physics-based molecular simulations with artificial intelligence methods to advance understanding of CRISPR-Cas9 conformational dynamics,...
- The National Institute of General Medical Sciences awarded the University of Utah $211,974 on March 11, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and validate a comprehensive evaluation system for T32 training programs. The project delivers validated survey instruments for trainees, mentors, program administrators, and program alumni, along with four supporting implementation resources: a survey administration manual covering timing,...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $2,001,691 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop PURGE, a computational toolkit for prioritizing guide RNAs in CRISPR epigenome editing applications. The research addresses a fundamental limitation in CRISPR-based epigenome editing: only 10–20 percent of guide RNAs targeting distal regulatory elements successfully...
- The National Institute of General Medical Sciences awarded the University of Utah $500,500 on March 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply nicotinic acetylcholine receptor targeted peptides for biomedical research. Over the five-year performance period through December 31, 2030, the University of Utah will develop a library of selective probes targeting nicotinic acetylcholine receptor (nAChR) subtypes currently lacking selective...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $526,805 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop episomal single-cell reporter assays for measuring the activity of hundreds to thousands of regulatory elements with tissue-specific resolution in whole developing embryos. The research focuses initially on enhancers as critical regulatory elements controlling gene expression timing and...
- The National Institute of General Medical Sciences awarded $423,500 to the University of Utah on August 15, 2026, to map inter-organ communication networks by identifying and characterizing circulating proteins that coordinate multi-organ functions under normal and disease conditions. The project integrates experimental and computational techniques to identify inter-organ signaling factors in blood, develop tools to determine tissue targets of circulating proteins, and apply AI-based...
The National Institute of General Medical Sciences awarded the University of Utah $423,500 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational and statistical tools for measuring and analyzing CRISPR genome editing outcomes. The recipient will create algorithms to quantify complex editing outcomes across diverse editor types and improve detection of unexpected editing byproducts that current methods miss. The University of Utah will establish statistical standards and frameworks for comparing editing results across experimental sites, enabling reproducible assessment of editor performance and detection of rare off-target events. The recipient will also design tools to process long-read sequencing data, which captures large insertions, deletions, and rearrangements that short-read sequencing methods fail to detect. These advances aim to transform how genome editing data are measured, interpreted, and compared, ultimately enabling development of safer and more effective gene editing technologies for research and clinical use. Performance occurs in Emigration Canyon, Utah, with a period of performance from August 1, 2026, through June 30, 2031. This is a Project Grant, the standard assistance type under NIGMS for investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 7/28/26 |