Project Grant R01GM165452
- The National Institute of General Medical Sciences awarded the University of Utah $423,500 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational and statistical tools for measuring and analyzing CRISPR genome editing outcomes. The recipient will create algorithms to quantify complex editing outcomes across diverse editor types and improve detection of unexpected editing byproducts that current methods miss. The University of Utah...
- The National Institute of General Medical Sciences, operating as part of the Department of Health and Human Services National Institutes of Health, awarded the University of Utah $423,500 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research investigating the biological functions, biosynthesis, and dynamic regulations of RNA chemical modifications. The research program addresses three key challenges: identifying proteins that...
- The National Institute of General Medical Sciences awarded the University of Utah $392,942 on May 22, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the regulation of single-cell migration in vivo. The award funds investigation into how focal adhesion structures form and function during cell migration in living organisms, specifically using zebrafish larval skin as a model system to directly visualize focal adhesion dynamics in highly...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Oklahoma Medical Research Foundation $805,745 on July 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to develop precision genome editing tools for functional characterization of genetic variants. The award funds development of a high-throughput, cost-effective platform for in vivo functional validation of human disease-associated genetic variants using zebrafish as a...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Massachusetts Medical School $460,625 on August 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to develop lipid nanoparticle technology for simplified CRISPR/CAS9 gene editing in Caenorhabditis elegans nematodes. The funded work addresses a bottleneck in C. elegans research where microinjection of CRISPR guides limits throughput for genome-wide mutagenesis...
- The National Institute of General Medical Sciences awarded the University of Utah $885,637 in project grant funding on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The University of Utah, through its Office of Sponsored Projects Division, will conduct a five-year investigation into the molecular and metabolic adaptations that enable apicomplexan parasites—particularly Plasmodium species that cause malaria—to survive and replicate within host cells....
- The National Institute of General Medical Sciences awarded the University of Utah $500,500 on March 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply nicotinic acetylcholine receptor targeted peptides for biomedical research. Over the five-year performance period through December 31, 2030, the University of Utah will develop a library of selective probes targeting nicotinic acetylcholine receptor (nAChR) subtypes currently lacking selective...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded the University of Illinois $526,483 on May 14, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop enhanced epigenome editing technologies for controlling mammalian gene expression. The award funds development of a toolkit of programmable epigenome editors capable of activating gene expression in vivo through three integrated aims. Aim 1...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $526,805 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop episomal single-cell reporter assays for measuring the activity of hundreds to thousands of regulatory elements with tissue-specific resolution in whole developing embryos. The research focuses initially on enhancers as critical regulatory elements controlling gene expression timing and...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded $314,500 to ST Jude Children's Research Hospital Inc. on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), classified as a Project Grant. The recipient will develop next-generation genome-editing tools centered on CRISPR-associated transposons (CASTs)—a novel class of RNA-guided integrases capable of inserting DNA...
The National Institute of General Medical Sciences awarded the University of Utah $556,000 on August 25, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance precise genome editing methods in zebrafish. The award funds development and optimization of a base-substitution editing technique using single-strand DNA donors and a nickase version of Cas9 (Cas9D10A) to direct homology-directed repair. The funded work will improve editing efficiency, establish and fully characterize method parameters and implementation limitations so investigators can design experiments confidently, and validate the approach across multiple genetic loci including essential genes. The recipient aims to make the technology readily portable and implementable by any researcher, addressing a critical bottleneck in zebrafish research where current genome modification methods are too inefficient for practical disease modeling and human variant functional testing. Work is performed in Salt Lake City, Utah, with a period of performance through April 30, 2030. The award is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $556.0k | 8/25/26 |