Project Grant R35GM165860
- The National Institute of General Medical Sciences awarded the University of California, Berkeley $329,491 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, to elucidate the molecular basis of necroptosis through a five-year project extending to May 31, 2031. The funded research investigates the ZBP1-RIPK3-MLKL necroptosis pathway, specifically how ZBP1 transitions from inactive to assembled states to engage RIPK3, how MLKL undergoes conformational...
- The National Institute of General Medical Sciences awarded $441,375 to The Regents of the University of California, doing business as University of California, Berkeley, on September 1, 2026, under the R35 (MIRA) program (CFDA 93.859, Biomedical Research and Research Training). The award funds a five-year project investigating how tissues integrate immune-cell derived signals to regulate inflammation, repair, and homeostasis. The research pursues three interconnected directions: dissecting how...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $381,176 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanoscale tools for studying membrane damage and repair and enable intracellular sensing. The project will uncover how cells detect, respond to, and repair damage to their plasma and nuclear membranes, and harness these processes for intracellular sensing. Theme 1 uses...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded Cincinnati Children's Hospital Medical Center $405,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct a five-year research program investigating the regulatory mechanisms of gasdermin-mediated pyroptosis. The research uses functional genomics, proteomics, and live cell imaging to study how gasdermin family proteins control pyroptosis, a highly inflammatory form of programmed cell...
- The National Institute of General Medical Sciences awarded $370,550 to the University of California, San Diego on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for development of the Intracellular Protein Organization Landscape (IPOL), a quantitative computational framework that characterizes cell types and states based on spatial protein organization rather than molecular composition. The award funds research integrating high-resolution imaging,...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $125,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant K99GM162992). The award funds research into biophysical mechanisms of mechanotransduction and cell morphology, examining how cells respond and adapt to biochemical and physical environmental cues. The project focuses on mechanotransduction signaling in response to substrate material...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $526,805 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop episomal single-cell reporter assays for measuring the activity of hundreds to thousands of regulatory elements with tissue-specific resolution in whole developing embryos. The research focuses initially on enhancers as critical regulatory elements controlling gene expression timing and...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $369,347 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct high-resolution structural analysis of megasynthases by cryo-electron microscopy. The project develops molecular tools and probes to enable structural visualization of protein-protein interactions within carrier protein-dependent biosynthetic pathways, including fatty acid synthase,...
- The National Institute of General Medical Sciences awarded $429,072 to the University of Connecticut Health Center on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanism of necroptosis mediated by the mixed lineage kinase-like (MLKL) protein. The research addresses the structure-activity relationship of MLKL, the terminal executioner of necroptosis—a pro-inflammatory form of lytic cell death implicated in cancer,...
The National Institute of General Medical Sciences awarded the University of California, San Diego $233,283 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how tissue environment shapes neutrophil cell death fate and function. The research integrates live tissue imaging, spatial transcriptomics, chromatin profiling, and genetic models to define the fundamental rules governing whether neutrophils undergo netosis, apoptosis, or pyroptosis across tissues and disease contexts. The work examines how tissue-derived cues, chromatin accessibility, developmental history, and temporal residency regulate neutrophil extracellular trap formation—specialized cell death that contributes to both antimicrobial defense and pathology in thrombosis, autoimmunity, ischemia, and tumor progression. Four interlocking research themes address tissue context calibration of neutrophil death fates, developmental origin and plasticity in netosis competence, net structures as physical barriers and scaffolds, and residency time progression from acute to chronic suppressive-dominant states. The award includes complementary analyses of human tissues alongside preclinical work. Performance runs through August 31, 2031, at UC San Diego's La Jolla, California campus. This is a Maximizing Investigators' Research Award (MIRA) for early-stage investigators.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $233.3k | 8/25/26 |