Project Grant R35GM165587
- The National Institute of General Medical Sciences awarded the University of Missouri System $418,822 on April 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance mechanistic understanding of membrane interfaces. The research addresses two primary areas: understanding the mechanism by which candidalysin, a peptide virulence factor secreted by Candida albicans, attacks host cell membranes by forming pores in lipid bilayers; and defining the mechanism of...
- The National Institute of General Medical Sciences awarded the University of Missouri System $364,623 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research dissecting the regulatory networks involved in elongation, division, and cell wall homeostasis in polarly growing bacteria. The project uses Agrobacterium tumefaciens as a model organism to determine the molecular mechanisms underlying polar growth and to understand the genetic...
- The National Institute of General Medical Sciences awarded the University of Missouri System $2.285 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop artificial intelligence methods for reconstructing protein complex structures from cryo-electron microscopy data and predicting mutated protein structures. The award funds research to address two key gaps in structural bioinformatics: the lack of automated, accurate methods for...
- The National Institute of General Medical Sciences awarded the University of Missouri System (operating as Curators of the University of Missouri) $427,526 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research into the functions and mechanisms of bacterial serine-threonine kinases. The research elucidates the fundamental role of post-translational protein modifications in bacterial cellular signaling, with emphasis on serine-threonine...
- The National Institute of General Medical Sciences awarded the University of Missouri System $425,974 on March 1, 2026, to elucidate plant-derived steroidal biosynthetic pathways and develop sustainable bioproduction platforms for high-value pharmaceutical steroids under the Biomedical Research and Research Training program (CFDA 93.859). The recipient will identify and characterize biosynthetic enzymes that convert simple plant sterols to specialized steroids, including cardenolides and...
- The National Institute of General Medical Sciences awarded Missouri University of Science & Technology $528,560 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structure, catalytic mechanism, and inhibition of flavin-dependent N-monooxygenases, enzymes essential to siderophore biosynthesis in pathogenic bacteria and fungi. The project performs detailed biochemical and structural studies of histamine N-monooxygenases from...
- The National Institute of General Medical Sciences awarded the University of Missouri System $811,983 on July 1, 2026, to operate a trans-disciplinary basic biomedical science predoctoral training program under the Biomedical Research and Research Training program (CFDA 93.859). The University of Missouri-Columbia will deliver a T32 training program for predoctoral students across four integrated PhD programs: Biochemistry, Biological Sciences, Biological Engineering, and Translational...
- The National Institute of General Medical Sciences awarded the University of Missouri System $429,797 on March 24, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct structure-function studies of apolipoprotein B100. The recipient will conduct biophysical research focused on understanding how apolipoprotein B (ApoB), one of the largest known proteins, functions in lipid transport and metabolism. The research uses state-of-the-art electron microscopy,...
- The National Institute of General Medical Sciences awarded Brandeis University $398,904 on July 8, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to synthesize thioaminoketal antimicrobial peptides and determine their mechanism of action. The funded work prepares four classes of cyclic, bioactive peptides with varying structural complexity and antimicrobial potency. A key innovation involves selective thiolation of dehydroamino acids to directly convert linear...
- The National Institute of General Medical Sciences awarded The Washington University $410,520 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research uncovering the molecular principles of intracellular electrochemistry. The recipient will explore fundamental physicochemical and electrochemical features of living systems; establish theoretical frameworks to understand how electrochemical features such as proton motive force define passive...
The National Institute of General Medical Sciences awarded the University of Missouri System $418,114 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop orthogonal strategies for chemoselective peptide macrocyclization. The funded work develops two new chemical methods for cyclizing peptides: a sulfur(VI)-fluoride exchange (SUFEX)-mediated cyclization method selective for tyrosine and a light-mediated cyclization method selective for lysine. The recipient will synthesize bioactive peptide analogs using these methods and evaluate the impact of cyclization on peptide structure, function, proteolytic stability, and cell permeability. The project aims to create chemical tools that expand the diversity of peptide architectures available for therapeutic development. Performance occurs in Columbia, Missouri, with period of performance from August 1, 2026, through March 31, 2031. The University of Missouri System, operating as the Curators of the University of Missouri, is the awardee. This is a Project Grant, the standard NIH mechanism for investigator-initiated biomedical research. NIGMS supports basic research that increases understanding of biological processes and provides the foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $418.1k | 7/27/26 |