Project Grant R35GM164314
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded The University of Texas Southwestern Medical Center $488,525 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), a Project Grant (R35GM162011). The award funds evolution-guided studies of mitochondrial activities and the host response to infectious agents. The research characterizes newly identified...
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $697,200 for Project Grant R01GM160511 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds investigation of Golgi ribbon structure and function in mammalian cells. The research employs biochemical, cell biological, and microscopy approaches to elucidate the molecular mechanisms by which RNA functions as a structural biopolymer that...
- The National Institute of General Medical Sciences awarded the University of Texas Health Science Center at Houston $423,576 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop machine learning-driven computational tools for interpreting electron cryo-microscopy and electron cryo-tomography data of complex biological assemblies. The project addresses significant gaps in current cryo-EM modeling software by building a unified framework to model...
- The National Institute of General Medical Sciences awarded Texas A&M Engineering Experiment Station $394,917 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop advanced label-free microscopy methods linking cell structure to mechanobiology. The work focuses on quantitative phase imaging and holotomography as nondestructive, non-contact tools for visualizing cytoskeletal structure and predicting cell viscoelasticity in live, unlabeled cells....
- The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $124,956 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel methodologies for studying nascent RNA dynamics within nuclear condensates. The funded research establishes APEX-EU-SEQ, a methodology integrating proximity-based biotinylation and metabolic RNA labeling to profile condensate-associated nascent RNA fluxes over time with...
- The National Institute of General Medical Sciences awarded the University of Texas at Dallas $1.928 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for a project grant investigating how cellular metabolism shapes embryonic development. The funded research integrates advanced imaging, genetic tools, and single-cell sequencing in the chordate model Ciona to examine how metabolic rewiring orchestrates gene regulatory networks during...
- The National Institute of General Medical Sciences awarded the University of Texas at Dallas $431,750 on February 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support five-year research into the mechanisms regulating kinetics and specificity of nuclear-cytoplasmic transport. The research addresses how nuclear pore complexes (NPCs) vary in number, post-translational modifications, and protein composition across cellular and developmental contexts, and how...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $2.23 million Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 3, 2025, through August 31, 2029. The grant funds a five-year research program focused on elucidating the catalytic mechanisms and regulatory roles of bacterial alarmone hydrolases—enzymes that degrade (p)ppGpp, a...
- The National Institute of General Medical Sciences (NIGMS), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Dallas $435,875 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing) to investigate how tissue-specific progenitor cell fate is governed by mesenchymal progenitors and sympathetic neurons during adult tissue regeneration. The recipient will use the postnatal mouse...
The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $556,694 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support structural and functional analysis of ciliary complexes, with work performed in Dallas, Texas through March 31, 2031. The award funds an integrated research program combining structural cell biology, disease-focused analysis, and technical innovation to advance understanding of ciliary dysfunction in human ciliopathies including hydrocephalus, infertility, chronic respiratory infection, and congenital heart disease. The research encompasses three directions: structural analysis of the ciliary axoneme using cryo-electron tomography and subtomogram averaging with comparative studies across organisms; structural mapping of the ciliary base and transition zone in motile and primary cilia using cryo-focused-ion-beam milling and cryo-ET, including studies of wild-type and disease-associated mutant cells; and technical innovation to overcome key cryo-ET limitations, including sample deuteration to reduce radiation damage and improve resolution, development of improved in situ tagging tools, and methods to enable imaging of thick tissues.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $556.7k | 8/4/26 |