Project Grant R35GM164244
- The National Institute of General Medical Sciences awarded The Wistar Institute of Anatomy and Biology $591,549 in a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on June 1, 2026, to investigate how the Integrator complex and PP2A phosphatase regulate RNA polymerase II transcriptional integrity. The research addresses the molecular basis of RNA polymerase II pausing and pause-release mechanisms. The recipient will determine how the INT-PP2A module—which recruits the PP2A...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $425,667 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of chromatin remodeling and histone deacetylation. The recipient's research program examines ATP-dependent chromatin remodelers, specifically CHD and ISWI ATPases, and sirtuins, NAD-dependent histone deacetylases, two enzyme families that dynamically regulate...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $924,095 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms controlling actin cytoskeleton dynamics. The research addresses four major knowledge gaps: the ARP2/3 complex's role in actin filament branching and regulation by nucleotide state and binding proteins; filament dynamics at barbed and pointed ends, including cooperative...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $460,771 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct basic research on the molecular mechanisms regulating zygotic genome activation during early embryonic development. The research addresses the transition from maternal to zygotic transcriptional control following fertilization, focusing on how pioneer transcription factors in the...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $419,939 on August 1, 2026, to conduct live-cell super-resolution imaging research on enhancer-mediated gene bursting under the Biomedical Research and Research Training program (CFDA 93.859). The research characterizes transcriptional condensates—assemblies of RNA Polymerase II, Mediator, and transcription activators—in mouse embryonic stem cells and examines how they regulate target gene expression...
- The National Institute of General Medical Sciences awarded $478,621 to The Trustees of The University of Pennsylvania on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing R35GM161389) to conduct basic research elucidating the epigenetic regulation and function of imprinted genes in mammals. The recipient will investigate the mechanisms by which parental identity of imprinted genes is established, maintained, and reprogrammed in the...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded $345,581 to the University of Pennsylvania on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to visualize and characterize how bacteria and archaea use DNA-bending proteins to fold genomic DNA into three-dimensional shapes that regulate CRISPR-associated integrase function during adaptive immunity to phage infection. The project will employ...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded The Trustees of the University of Pennsylvania $1.3 million on July 1, 2026, under the Biological Sciences program (CFDA 47.074) to investigate the structural and biochemical mechanisms of the HIRA/HIR histone chaperone complex and its role in chromatin regulation. The project, titled "Dissecting the HIRA/HIR Chaperone Complex in the Chromatin Landscape," seeks to establish a mechanistic...
- The National Institute of General Medical Sciences awarded $406,250 to the University of Pennsylvania on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop statistical and computational methods for analyzing complex multimodal biological datasets. The recipient will develop correlated latent factor models to extend multi-omic inference capabilities across complex study designs, including model-based imputation methods for handling missing data...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $406,250 on March 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance nucleic acid chemistry and synthetic biology for RNA therapeutics. The research program develops de novo xeno nucleic acids (XNAs)—synthetic nucleic acid analogs with modified backbones that enhance nuclease resistance and extend half-life—to expand the genetic toolkit for RNA silencing and...
The National Institute of General Medical Sciences awarded the University of Pennsylvania $441,826 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular basis of transcription initiation at eukaryotic promoters in chromatin. The research will isolate and dissect pre-initiation complex (PIC)-mediator-coactivator complexes representing states from initiation to early elongation, using biochemical and structural approaches including cryo-electron microscopy and cross-linking mass spectrometry. The work will examine how promoter nucleosomes regulate transcription initiation through collaboration with chromatin remodelers, histone modifiers, and histone chaperones, and will validate structural models through functional analyses. The long-term goal is to define mechanisms underlying transcription initiation dysregulation implicated in cancer, neurodevelopmental disorders, and aging-related processes. The award is structured as a project grant with a period of performance from September 1, 2026, through April 30, 2031. Work is performed in Philadelphia, Pennsylvania. The University of Pennsylvania serves as the recipient institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $441.8k | 9/1/26 |