Project Grant R35GM164224
- Federal Grant Award Summary The University of Pittsburgh received a $437,250 Project Grant awarded August 15, 2025, by the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859). The five-year project, concluding July 31, 2030, focuses on developing advanced computational approaches for integrating single-cell multi-omics data across diverse research cohorts. The research addresses critical challenges in precision medicine by...
- Federal Project Grant Award Summary The University of Pittsburgh received a $437,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2030. This award supports research aimed at improving the characterization of individualized treatment effects (ITEs) in critical illness, specifically focusing on sepsis and acute respiratory distress syndrome...
- Federal Grant Award Summary The University of Pittsburgh received a $1,396,731 Project Grant award from the National Institute of Environmental Health Sciences under the Medical Library Assistance program (CFDA 93.879) effective September 1, 2025, through August 31, 2029. The project develops a computational framework for automated quality assessment and curation of biological models at scale. The initiative standardizes and automates the iterative processes of model assembly, documentation,...
- Federal Grant Award Summary The University of Pittsburgh received a $433,710 Project Grant award dated August 15, 2025, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). Led by Principal Investigator Joo Heung Yoon, this project will design a comprehensive machine learning (ML)-driven prescriptive clinical decision support system focused on shock and associated critical care conditions in intensive care...
- Federal Grant Award Summary The University of Pittsburgh received a $371,175 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2026, through March 31, 2031. This award supports fundamental research into mechanistic studies and chemoselectivity improvements of Birch-type reduction methods in organic chemistry. The research aims to develop unprecedented chemoselectivity to...
- Summary of Federal Project Grant Award The University of Pittsburgh received a $237,007 Project Grant award from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) effective September 1, 2025 through August 31, 2027. The award supports development of an Open Science Platform for Cancer Dependency Prediction and Analysis utilizing deep learning and large language models. The project directly addresses the NIH's "Building...
- Federal Project Grant Award Summary The University of Pittsburgh received a $401,939 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on August 8, 2025, with a completion date of June 30, 2030. This research project focuses on investigating gram-positive secretion chaperone-client interactions to advance understanding of post-translocation protein folding and secretion mechanisms in...
- Federal Project Grant Award Summary The University of Pittsburgh received a $417,620 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with completion targeted for December 31, 2030. This award supports computational research developing statistical methods to quantify natural selection and predict evolutionary dynamics from temporal genetic data—sequences and phenotypes sampled...
- Federal Project Grant Award Summary The University of Pittsburgh received a $275,303 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 1, 2025, with completion targeted for July 31, 2030. This five-year research initiative develops predictive stochastic modeling frameworks to understand noise and variability in microbial cell proliferation across molecular, cellular, and...
- Federal Grant Award Summary The University of Pittsburgh received a $408,829 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective September 1, 2025 through August 31, 2027. The award supports development of an integrative framework for surface protein imputation in spatial biology applications. The project will advance understanding of tumor microenvironments by creating machine learning approaches to predict surface protein...
The University of Pittsburgh received a $437,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 5, 2026, with completion targeted for January 31, 2031. The award funds development of a generalizable computational platform that integrates systemic omics data (proteomics, metabolomics, and transcriptomics), imaging-derived phenotypes, and genetic information to model early tissue vulnerability across major organ systems including the brain, heart, lungs, liver, kidneys, pancreas, and muscle. The platform will deliver three primary products: (1) spatially resolved risk prediction tools linking molecular profiles to imaging phenotypes while accounting for genotype-biomarker interactions through polygenic risk scoring; (2) individualized molecular mechanism inference to stratify patient-level susceptibility; and (3) a deep learning-based drug repurposing tool for therapeutic discovery targeting inflammation, metabolism, fibrosis, and mitochondrial stress pathways. To ensure broad applicability, the project will harmonize multimodal data across cohorts and disseminate standardized analytical pipelines and prediction tools, addressing limitations of traditional biomarkers by providing region-specific, mechanistically interpretable insights to support precision health applications and guide targeted clinical interventions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $437.3k | 5/5/26 |