Project Grant R35GM164064
- Federal Grant Award Summary The National Institute of General Medical Sciences awarded UC Berkeley a $226,560 Project Grant effective March 1, 2026, through December 30, 2028, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports the development of new catalytic methods and modular synthesis approaches for creating saturated, nitrogen-containing heterocyclic building blocks—critical pharmaceutical precursors currently underrepresented in commercial...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of California, Berkeley a Project Grant totaling $441,375 under the Biomedical Research and Research Training program (CFDA 93.859) effective April 1, 2026 through March 31, 2031. The award funds fundamental research investigating the cellular and developmental mechanisms by which animals respond to intracellular beneficial microorganisms. The research utilizes the small sea...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UC Berkeley $119,907 under the Biomedical Research and Research Training program (CFDA 93.859) for a two-year project period (August 1, 2025 – July 31, 2027). This Project Grant funds fundamental research to advance understanding of TnpB, a compact transposon-encoded RNA-guided endonuclease with significant potential for genome-editing applications. The research delivers three primary products: (1) a...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Regents of the University of California, doing business as University of California, Berkeley, a Project Grant totaling $361,952 under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, with a completion date of June 30, 2030. This award funds fundamental research aimed at mapping and predicting the sequence-function landscape of biomedically...
- Federal Grant Award Summary The University of California, Berkeley received a $246,263 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026 through June 30, 2031. This award supports fundamental biomedical research investigating post-transcriptional regulatory networks and the Integrated Stress Response (ISR) pathway. The research will comprehensively map cofactors engaged...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $491,739 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 1, 2025, with completion targeted for August 31, 2030. This award supports fundamental research investigating the molecular mechanisms underlying transcriptional circuit evolution in yeast species, specifically within the...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UC Berkeley $617,574 under the Biomedical Research and Research Training program (CFDA 93.859) for fundamental research into site-specific non-LTR retrotransposon mechanisms of mobility and transgene insertion. The project, active from March 9, 2026 through February 28, 2030, supports investigation of how non-LTR retrotransposon reverse transcriptases insert DNA sequences into animal genomes, with...
- Federal Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded UC Berkeley $87,250 under the Biological Sciences program (CFDA 47.074) beginning September 1, 2025, with completion by August 31, 2027. This Project Grant supports the development of genomic language models (GLMs) to predict optimal fungal genomes for enhanced commercial protein production. The primary deliverables include a hierarchical genome-to-phenotype model (G2PM) for...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $150,104 to The Regents of the University of California, San Francisco under the Biomedical Research and Research Training program (CFDA 93.859) on August 8, 2026, with a project completion date of February 29, 2028. The award funds de novo design of allosterically regulated proteins to study intramolecular signal transduction. The research aims to design novel helical bundle proteins from...
- Federal Grant Award Summary The University of California, San Francisco received a $124,767 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) effective May 1, 2026 through April 30, 2028. The award funds research focused on de novo protein design for catalysis and fluorescence imaging applications. The investigator will advance fundamental understanding of protein-small molecule interactions through...
The National Institute of General Medical Sciences (NIGMS) awarded UC Berkeley $387,596 under the Biomedical Research and Research Training program (CFDA 93.859) on June 1, 2026, for a project titled "Engineering Specialized Organelles in Yeast for Compartmentalized Production of Therapeutics." The award supports fundamental research to re-engineer peroxisomes and vacuoles as synthetic, specialized organelles capable of compartmentalizing metabolic pathways in Saccharomyces cerevisiae (baker's yeast). The project will establish design rules for controlling organelle biogenesis, membrane permeability, protein import efficiency, and selective molecular trafficking—key properties necessary for engineering complex therapeutic molecule synthesis within a unicellular microorganism. The research will generate platform strain technologies that enable Saccharomyces cerevisiae to mimic tissue-level compartmentalization found in plants, facilitating the fermentation-based production of natural product therapeutics such as benzylisoquinoline alkaloids. By distributing engineered metabolic pathways across the peroxisome, vacuole, and cytoplasm, the project will advance both fundamental understanding of organelle biology and practical tools for metabolic engineering of clinically relevant compounds. The project period extends through February 28, 2031.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $387.6k | 5/20/26 |