Project Grant R01GM169340
- Federal Project Grant Award Summary The University of Chicago received a $487,525 Project Grant award dated March 1, 2026, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research in evolution-based understanding and design of proteins, with a project completion date of December 31, 2030. The research deliverables include experimentally validated computational models for protein...
- Federal Grant Award Summary The University of California, Berkeley received a $723,904 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through June 30, 2030. The award supports the development of experimental methods and assays to systematically explore the mutational landscape of biomedically relevant proteins, with particular focus on CRISPR-Cas genome editing...
- Federal Project Grant Award Summary The University of California, Berkeley received a $510,183 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 17, 2026, with completion expected February 28, 2031. The Song Lab will deliver robust and scalable machine learning (ML) and statistical methods designed to advance genomics research. The research team, comprising computer scientists,...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Regents of the University of California, San Francisco a $1.453 million Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) on September 5, 2025, with completion anticipated on May 31, 2030. This award supports research aimed at bridging the gap between structural prediction and experimental reality in structural biology by developing advanced simulation-based...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $124,767 to the University of California, San Francisco under the Biomedical Research and Research Training program (CFDA 93.859) effective May 1, 2026 through April 30, 2028. This Project Grant supports de novo protein design research focused on creating proteins that bind small molecules and catalyze chemical reactions. The research builds on the principal investigator's recent success designing...
- Federal Project Grant Award Summary Princeton University's Office of Research and Project Administration has been awarded $1,968,575 through the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) for a project titled "Computational Approaches for Elucidating Proteomes and Interactomes." The award, effective September 15, 2025, with completion scheduled for August 31, 2029, supports the development of advanced...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $420,520 Project Grant to the Regents of the University of California at Riverside, effective July 1, 2026 through March 31, 2031, under the Biomedical Research and Research Training program (CFDA 93.859). This award funds a five-year research initiative focused on mechanistic studies of CRISPR-Cas9 genome editing through integrated molecular simulations and artificial intelligence-driven approaches....
- Federal Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded UC Berkeley $87,250 under the Biological Sciences program (CFDA 47.074) beginning September 1, 2025, with completion by August 31, 2027. This Project Grant supports the development of genomic language models (GLMs) to predict optimal fungal genomes for enhanced commercial protein production. The primary deliverables include a hierarchical genome-to-phenotype model (G2PM) for...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded University of California, Berkeley a Project Grant totaling $401,250 under the Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated computational framework for predicting drug molecular crystal solubility. Awarded on September 15, 2025, with a completion date of July 31, 2030, this five-year initiative will deliver machine learning potentials (MLPs) based on...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Regents of the University of California, San Francisco $562,484 under the Biomedical Research and Research Training program (CFDA 93.859) for a five-year project (May 1, 2026–April 30, 2031) focused on developing next-generation visualization and analysis software for multiscale molecular modeling. The project will advance scientific discovery in biomedical research by creating integrated...
The National Institute of General Medical Sciences (NIGMS) awarded $206,410 to the University of California, Berkeley on July 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the effects of AlphaFold2—a deep learning system that predicts protein three-dimensional structures—on structural biology and biomedical research productivity. The project delivers comprehensive empirical analysis examining how this artificial intelligence tool has reshaped the scientific landscape across three specific research aims: (1) analyzing labor market impacts on structural biologists' careers, including displacement effects for early-career and established researchers; (2) assessing changes in the rate and direction of experimental protein structure determination and individual researcher productivity; and (3) evaluating downstream consequences for biomedical research and pharmaceutical drug discovery pipelines. The research employs causal inference methodologies combined with administrative datasets including the Protein Data Bank, UniProt/Swiss-Prot, the AlphaFold Database, and OpenAlex, supplemented by an original survey of active structural biologists. This project is scheduled for completion by June 30, 2029, and will generate systematic evidence on how specific AI tools alter the pace, direction, and productivity of science—an area currently lacking robust empirical documentation. The findings will inform policy and institutional decision-making regarding AI integration in scientific research while advancing understanding of protein structure's foundational importance to disease diagnosis and pharmaceutical development.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $206.4k | 7/3/26 |