Project Grant R35GM163671
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Regents of the University of California at Riverside $224,100 on September 15, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate epigenetic factors controlling epidermal stem cell longevity in adult skin. The research examines how epigenetic regulators, specifically polycomb repressive complexes, function in hair follicle stem cells and interfollicular...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded the University of California, Davis $1.624736 million under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026. The award funds research into morphological reprogramming of the endoplasmic reticulum by cellular mucins. The project tests the hypothesis that transmembrane mucins act as membrane curvature generators on the luminal face of the endoplasmic...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (part of the National Institutes of Health) awarded the University of California, Los Angeles $150,152 on March 27, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to characterize migratory cell differentiation in developing zebrafish skin. The research will use live imaging, antibody staining, single-cell RNA sequencing, and pseudotime analysis to characterize the development of...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of California, Los Angeles $493,148 on September 3, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to characterize mechanisms of intra-epithelial migration in the developing epidermis. The project uses live imaging of developing zebrafish to investigate how specialized cell types arising from basal epidermal cells—specifically...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $384,394 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular determinants of lipid-protein recognition through computational and experimental approaches. The research integrates deep-learning, molecular dynamics simulation, and de novo protein design to characterize biophysical interactions governing binding affinity and...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $526,805 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop episomal single-cell reporter assays for measuring the activity of hundreds to thousands of regulatory elements with tissue-specific resolution in whole developing embryos. The research focuses initially on enhancers as critical regulatory elements controlling gene expression timing and...
- The National Institute of General Medical Sciences awarded Icahn School of Medicine at Mount Sinai $336,000 on September 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate apical junction fluidity control during epithelial morphogenesis. The research examines the role of Prickle 2 (PK2), a core component of the planar cell polarity pathway, in controlling the flexibility and directionality of junctional remodeling. The work focuses on...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $125,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant K99GM162992). The award funds research into biophysical mechanisms of mechanotransduction and cell morphology, examining how cells respond and adapt to biochemical and physical environmental cues. The project focuses on mechanotransduction signaling in response to substrate material...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $381,176 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanoscale tools for studying membrane damage and repair and enable intracellular sensing. The project will uncover how cells detect, respond to, and repair damage to their plasma and nuclear membranes, and harness these processes for intracellular sensing. Theme 1 uses...
The National Institute of General Medical Sciences awarded the University of California, San Diego $2.2 million in a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on August 5, 2026, to support research on morphogenesis and maintenance of the epidermis. The funded research explores how specific molecules function in patterning, morphogenesis, and maintenance of skin using the nematode C. elegans as a model system. The program combines molecular genetics, advanced imaging, and biochemistry to address key questions in epidermal biology, including the patterning of the epidermal apical extracellular matrix, the nature of the skin permeability barrier, and the roles of extracellular vesicles in skin morphogenesis. Results are expected to illuminate fundamental aspects of barrier epithelial biology with relevance to skin fibrosis and chronic wound healing defects. Performance occurs in La Jolla, California, with a period of performance from August 5, 2026, through July 31, 2030. The award is classified as a Project Grant, an assistance type that provides funding for discrete, circumscribed research projects of specified duration and defined objectives.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.2m | 8/5/26 |