Federal Grant Award Summary

The University of California, Davis received a $402,051 Project Grant award dated February 26, 2026, from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a multi-glycomic characterization research initiative extending through December 31, 2030, focused on developing integrated analytical platforms and methodologies to advance understanding of cell membrane glycosylation and protein interactions.

The research deliverables include: (1) development of automated glycomic analysis platforms with sample preparation capabilities to profile N- and O-glycans on proteins and glycolipids; (2) creation of software for automated structural annotation to identify linkages and structural features of glycans, including sialic acids and fucoses; (3) pathway analysis combining glycomic profiles with transcriptomic data to identify key synthetic enzymes as therapeutic targets; (4) newly developed quantitative crosslinking strategies to reveal protein-glycan interaction networks; and (5) applied analysis of insulin resistance in cell lines to demonstrate how protein glycosylation differences affect cellular function. These integrated workflows address aberrant glycosylation as a disease hallmark, with implications for identifying biomarkers and therapeutic intervention targets across cancer and infectious disease domains.