Project Grant R35GM161448
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $433,125 to the University of California, Los Angeles (UCLA) effective August 1, 2025, through May 31, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). This Project Grant supports a multidisciplinary research initiative investigating how genomic variation drives functional changes at molecular, cellular, and phenotypic levels. The research integrates cutting-edge...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $363,570 Project Grant to the University of California, Los Angeles (UCLA) effective March 15, 2026, through February 28, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). This award funds the development of integrative computational and analytical methods to reconstruct three-dimensional (3D) genome structures from single cells by combining imaging data with...
- Federal Project Grant Award Summary The University of California, Los Angeles (UCLA) received a $420,984 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. This award supports the development of statistical methods and computational approaches to interpret deep mutational scanning (DMS) data, a high-throughput experimental technique used...
- Federal Project Grant Award Summary The University of California, Los Angeles received a $267,098 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) awarded August 1, 2025, with completion targeted for April 30, 2029. The award supports the development of statistical and computational methods for inferring Gene Regulatory Networks (GRNs) from large-scale RNA sequencing data. The research addresses two...
- Federal Project Grant Award Summary The University of California, Davis received a $432,417 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded April 1, 2026, with completion targeted for January 31, 2031. This award supports investigator-initiated fundamental biomedical research examining the mechanisms by which extracellular matrix (ECM) mechanical properties regulate cellular...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of California, Los Angeles a $433,125 Project Grant effective September 1, 2025 through August 31, 2030 under the Biomedical Research and Research Training program (CFDA 93.859). This award supports the development of efficient algorithms for rapid searching and identification of known and novel small molecules within large mass spectral databases. The research addresses a...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant of $286,729 to the University of California, Los Angeles under the Biomedical Research and Research Training program (CFDA 93.859) on March 1, 2026, with a completion date of January 31, 2031. This award supports fundamental research into the dynamics of eukaryotic translation and messenger RNA (mRNA) decay, specifically investigating how cells distinguish between normal and aberrant...
- Federal Project Grant Award Summary The University of California, San Diego received a $327,019 Project Grant award dated July 25, 2025, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research through April 30, 2030, focusing on developing innovative biophysical and computational frameworks to understand how cells transform during embryogenesis and stem cell differentiation. The...
- Federal Grant Award Summary Rockefeller University received a $395,499 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded April 1, 2026, with completion targeted for February 28, 2031. The research focuses on elucidating cytoskeletal force-sensing mechanisms and mechanotransduction—the cellular processes by which mechanical signals from the environment are converted into biochemical...
- Federal Project Grant Award Summary The University of California, San Francisco received a $158,240 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 5, 2026, with completion targeted for November 30, 2027. This award supports investigator-initiated basic research aimed at elucidating the mechanical mechanisms by which E-cadherin regulates actomyosin network organization...
The University of California, Los Angeles (UCLA) received a $433,125 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 5, 2026, with completion scheduled for January 31, 2031. The award supports the Rowat Lab's research initiative titled "Mapping the Mechanome: A Systems-Level Understanding of Mechanical Mediators and Pathways," which aims to develop a comprehensive, systems-level understanding of cellular mechanobiology—the genes, proteins, and pathways that regulate cellular mechanical properties and behaviors. The research deliverables include identification of novel mediators of cell mechanical behaviors through an unbiased genome-wide pooled short hairpin RNA (shRNA) screening approach utilizing UCLA's proprietary high-throughput cell filtration platform. The project will generate complementary measurements of cell mechanics, force generation, and cellular motility across multiple cell types to validate screening results. This fundamental research is designed to advance understanding of mechanical signaling in diverse physiological and disease contexts, including muscle regeneration, cancer progression, and cellular reprogramming, ultimately enabling predictive control over cellular behaviors and supporting applications in tissue engineering and cellular intervention strategies.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $433.1k | 3/5/26 |