Project Grant R35GM158059
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of efficient and accurate methods for identifying novel natural product small molecules from complex mass spectral datasets. The $275,484 award, which began on Sep 1, 2023 and runs through Aug 31, 2024, will enable the grantee, Chemia Biosciences, Inc., to integrate genome mining with computational metabolomics to...
- This $316,825 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to advance the field of native mass spectrometry (MS) analysis. The research project will develop an innovative intact mass deconvolution method to significantly improve the speed, accuracy, and user-friendliness of proteins and nucleic acid molecular weight determination using MS. The key objectives are to implement...
- This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351 - Research Infrastructure Programs) provides $1,574,994.00 to the University of California, Los Angeles (UCLA) to acquire a high-resolution tandem mass spectrometer. The instrument will support structural characterization of a broad range of large biological and synthetic molecules for over 11 NIH-funded research projects at UCLA. The research aims to advance...
- The federal Project Grant award of $420,984.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop statistical methods for analyzing deep mutational scanning (DMS) data. The research aims to improve the interpretation of DMS experiments, which can measure how genetic variants affect protein function, in order to better understand the mechanisms underlying basic biology and...
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $423,330 project grant to the University of Kansas Center for Research Inc. The grant, effective August 1, 2025 through June 30, 2030, focuses on developing innovative technologies to enable new discoveries in biomedical research using mass spectrometry. The key products to be delivered include: A completely noninvasive, non-painful sampling method...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluid Discovery, Inc., a San Francisco-based biotechnology company, to develop a "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." The award supports the development of a commercial prototype for Fluid Discovery's novel screening platform, which combines scalable hardware,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,316,016 Project Grant under CFDA Program 93.859 (Biomedical Research and Research Training) to the University of California, Irvine (UCI) to develop a novel biosensing platform for label-free, single-molecule detection at ultra-high speeds using metasurface-enhanced coherent Raman scattering. The 4-year project, running from September 2025 to August 2029, aims to overcome fundamental speed limitations in surface-enhanced...
- This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing...
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop efficient algorithms for identifying known and novel small molecules in complex samples using mass spectral database searches. The $433,125 award to the University of California, Los Angeles (UCLA) over a 5-year period (9/1/2025 - 8/31/2030) will fund research to address the challenge of rapidly searching large mass spectral databases containing millions or billions of reference spectra to identify the molecules present in a given sample. The research will focus on improving the speed and accuracy of these database search techniques, which currently take weeks or even years per query, to enable more efficient characterization of small molecules in various life science applications such as metabolomics, natural product discovery, and clinical diagnostics.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $433.1k | 8/21/25 |