Project Grant R35GM161407
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $451,000 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for discovery and engineering of enzymes that modify amino acids and peptides for use as synthetic tools in biomedical research. The research develops methods to discover, characterize, and engineer enzymes and metabolic pathways involved in amino acid and peptide modification. The work focuses on...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $2,993,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemistry-driven tools for studying protein function through intein-mediated protein splicing. The research focuses on three major areas: exploitation and extension of protein transposition technology to replace designated internal regions of folded proteins or protein complexes with...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $688,506 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct integrative genomic analyses of human evolution and complex traits in African populations. The research applies an integrative evolutionary genomics approach incorporating genomic, metabolomic, proteomic, microbiome, epigenomic, and transcriptomic data combined with detailed...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $2,227,666 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support chemical approaches to investigating post-transcriptional RNA regulation through the Kleiner Group at Princeton. The funded research applies chemical biology, proximity labeling, and mass spectrometry methods to map and characterize the spatial distribution and subcellular dynamics of...
- Federal Project Grant Award Summary Princeton University's Office of Research and Project Administration has been awarded $1,968,575 through the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) for a project titled "Computational Approaches for Elucidating Proteomes and Interactomes." The award, effective September 15, 2025, with completion scheduled for August 31, 2029, supports the development of advanced...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $451,000 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated experimental and computational platform for mapping, modulating, and modeling intercellular forces in living tissues. The research program establishes scalable technologies combining flexible microfabricated bioelectronic sensor-actuator devices, high-speed volumetric optical...
- The National Institutes of Health National Human Genome Research Institute awarded New York University $466,125 on May 18, 2026, under CFDA 93.172 (Human Genome Research) to support cross-species analysis of regulatory genomic function using synthetic regulatory genomics. The award funds development and application of the BIG-IN genome engineering technology to characterize regulatory DNA function across a phylogenetic tree. The recipient will analyze model genomic loci in mouse embryonic stem...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $812,500 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop statistical methods and computational tools for polygenic risk score prediction and discovery of disease-causal gene pathways. The research program develops novel methods for building polygenic risk scores (PRS) in heterogeneous and admixed populations by incorporating continuous global and...
- The National Institutes of Health National Human Genome Research Institute awarded Yale University $2.618 million on July 6, 2026, under the Human Genome Research program (CFDA 93.172) to develop advanced computational tools for de novo genome assembly and assembly-based genomic analysis. The project, titled "Toward Comprehensive Genomic Analysis Through De Novo Genome Assembly," will produce three deliverables. First, the recipient will develop a real-time assembly algorithm that...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded $227,652 to The Trustees of Princeton University on June 26, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop stereoselective photoenzymatic methods for oxygen- and nitrogen-centered radical transformations mediated by pyridoxal 5'-phosphate cofactors. The project will leverage pyridoxal...
The National Institute of General Medical Sciences awarded The Trustees of Princeton University $451,000 on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel computational and statistical methods for interpreting human genomic variation and to construct high-quality, haplotype-resolved de novo assembled genomes from individuals in understudied populations. The work encompasses methodological advances in phasing and accuracy of genomes generated from long-read sequencing data, population genetics inference directly from pangenome graphs, and detailed analysis of archaic hominin admixture, including identification and interpretation of Neanderthal and Denisovan introgressed sequences in previously inaccessible genomic regions. These efforts will generate datasets providing insights into sequence and structural variation in complex genomic regions, facilitate population genetics and evolutionary inferences, and contribute to more inclusive genomic research. Performance occurs at Princeton, New Jersey. The period of performance runs through March 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 8/4/26 |