Project Grant R35GM160469
- This federal Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) provides $399,227 to the University of Oregon to investigate the mechanisms of host-pathogen evolution and their impact on bacterial colonization, nutrient acquisition, and immune evasion. The research will utilize phylogenetic, biochemical, molecular genetics, cell biology, and microbiology approaches to study rapidly evolving host and...
- This federal Project Grant award of $522,764, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a targetable transposase platform for precise gene integration in human cells. The project seeks to optimize a PiggyBac transposase system to efficiently deliver large DNA fragments to specific genomic locations, overcoming limitations of existing gene editing technologies. Key objectives...
- This federal Project Grant award of $275,303 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), with a project period from August 1, 2025 to July 31, 2030. The goal of this grant is to develop predictive stochastic models of microbial proliferation that bridge the molecular, cellular, and population scales. Specific objectives include: (i) investigating the effects of molecular noise...
- The National Institute of General Medical Sciences (NIGMS) awarded a $258,986 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Arkansas to conduct research on "Decoding Gene-Environment Interactions in Complex Traits via Multi-Omics Approaches". The five-year project aims to unravel the genetic basis of complex trait variation and novel trait evolution through experimental and computational methods, including comparative,...
- The federal Project Grant award of $431,750.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award was made to Rutgers, The State University of New Jersey on August 12, 2025, with a planned ultimate completion date of May 31, 2030. The grant supports research to understand the impact of ecological interactions on mutant fitness and evolution in microbes. The research aims to develop...
- This federal Project Grant award of $148,680.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support the development of a new Ph.D. training program in Molecular Biophysics of Complex Systems (MBCS) at Oregon State University (OSU). The program will establish an interdisciplinary research and education center focused on three key areas: 1) data modeling and mining using computational...
- This federal Project Grant award of $572,553.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the pleiotropic effects of mucoid-based phage resistance in Escherichia coli populations. The research objective is to test predictions about the trade-offs between phage resistance, antibiotic resistance, and bacterial virulence. The University of Wisconsin - Milwaukee will conduct this...
- This federal Project Grant award of $393,718 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to determine the biogeography of plant and microbial-derived redox-active small molecules and their combinatorial effects on microbial growth in soil environments. The research aims to improve understanding of how antibiotic production by soil bacteria and their microbial neighbors shapes microbial community...
- This $294,060 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS, CFDA 93.859 Biomedical Research and Research Training program) supports research by The Trustees of Princeton University to investigate two areas of biophysical principles in living systems: (1) how the spatial structure and dynamics of bacterial communities affect their quorum sensing processes, and (2) the mechanisms controlling the formation and function of intracellular biomolecular...
- This $603,307 federal Project Grant, awarded by the National Science Foundation under the Biological Sciences (CFDA 47.074) program, aims to identify the genetic mechanisms controlling plant-microbiome interactions in the model legume Medicago truncatula. The 5-year project, with a start date of March 1, 2025, will leverage extensive resources in Medicago to map the genetic basis of microbiome variation and validate the functional significance of candidate genes. Additionally, the project will...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), provides $408,375.00 to Oregon State University to uncover the rules governing the spread of mobile genetic elements (MGEs) in microbes. The project aims to characterize MGE compatibility at multiple scales, from individual MGE-strain interactions to MGE-microbiome dynamics, using plasmids in the Agrobacteria/Rhizobia complex as a model system. Key objectives include: 1) Mapping plasmid incompatibility by analyzing replication and transfer loci diversity, and other MGE-blocking mechanisms like restriction-modification systems, 2) Investigating co-evolution between MGEs and host chromosomes to maintain compatibility. The project will leverage Oregon State University's expertise in microbiology, genetics, and bioinformatics to advance fundamental understanding of horizontal gene transfer, a critical driver of microbial evolution and host-microbe interactions. This 5-year project started on August 18, 2025 and is scheduled for completion by July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $408.4k | 8/7/25 |