Project Grant R35GM160220
- This federal Project Grant award of $360,247, granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms underlying the function and regulation of signaling effectors associated with type III CRISPR-Cas systems in microbes. The research aims to advance the understanding of how these RNA-guided immune systems in bacteria and archaea use cyclic nucleotide second...
- The National Institute of General Medical Sciences (NIGMS) awarded a $557,900 Project Grant to the Massachusetts Institute of Technology (MIT) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds a long-term research strategy to study ongoing adaptation and selective forces within human microbiomes. Using a culture-dependent genomic approach, the project aims to characterize within-person evolution over a dozen microbial species found in the skin, vagina,...
- This $408,375 federal Project Grant awarded on August 18, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to uncover the rules governing the spread of mobile genetic elements (MGEs) in microbes. The project aims to characterize MGE compatibility and how MGEs and microbial chromosomes co-evolve to maintain compatibility, using plasmids in the Agrobacteria/Rhizobia complex as a model...
- This two-year, $138,000 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund postdoctoral research exploring the effects of rapid evolution on alternative community states at multiple spatial scales. The fellow, Lucas Nell, will conduct laboratory experiments and develop mathematical models to study how trait evolution influences the composition of alternative microbial community states in monkeyflower nectar and their prevalence across a...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) federal Project Grant award of $1,180,492 to the University of Pennsylvania will fund research to investigate how beneficial microbes affect the evolution of plant defense traits. The project aims to determine how genetic variation in microbial symbionts influences heritable variation in host plant defense characteristics, such as leaf hairs that protect against insect damage. Additionally, the project will train...
- This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the mechanisms of evolution in host-pathogen interactions. The $399,227 award to the University of Oregon aims to investigate how rapid evolution of animal and bacterial cell surface receptors impacts colonization and immune evasion. The research will use phylogenetic methods, biochemistry, molecular...
- This federal Project Grant award of $361,416 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by Arizona State University (ASU) on the mechanisms of mammal-microbial coevolution and its implications for host health. The research aims to: 1) Identify codiversified microbial taxa and traits across various body sites and populations of Peromyscus deer mice; 2) Investigate whether host...
- This $985,496 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by the University of Rochester to develop an innovative platform for controlling and stabilizing microbial communities. The project aims to leverage horizontal gene transfer, specifically through plasmid conjugation, to dynamically balance growth rates and community composition, creating programmable microbial populations capable of maintaining stability across...
- This Project Grant award for $2,158,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Rutgers, The State University of New Jersey to investigate how the host metabolism impacts immune responses during bacterial infections. The research aims to deepen the mechanistic understanding of how host metabolic activities influence immune cell activation and function, with a focus...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $431,750 in funding to Rutgers, The State University of New Jersey to support research on the "Impact of Ecological Interactions on Mutant Fitness and Evolution in Microbes". The research aims to develop principles for understanding how ecological interactions, such as cross-feeding, affect the fitness of microbial mutations and subsequent evolutionary trajectories. This 5-year project seeks to address three key questions in this area, with the goal of improving the ability to predict microbial evolution in different environments, which has applications in areas like treating infectious diseases and personalized medicine.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 8/12/25 |