Project Grant R35GM160213
- The federal Project Grant award of $420,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to identify the molecular mechanisms of mitochondrial dysfunction in pathological stress conditions. The primary objective is to investigate the processes of oxidative phosphorylation and mitochondrial membrane potential disruption, which can lead to cell death and tissue damage in various diseases....
- This federal Project Grant award, titled "DECODING MITOCHONDRIAL AAA PROTEASE SPECIFICITY", was provided by the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) for $382,931 on September 1, 2025. The award supports fundamental scientific research and advanced training across diverse areas of biomedical science, with a focus on understanding biological processes and developing foundational knowledge for disease diagnosis,...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
- This federal Project Grant award of $237,874 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the upstream regulation of mitochondrial bioenergetics by the mitochondrial acyl carrier protein (MTACP). The research aims to uncover how MTACP, which sits at the intersection of nutrient inputs and energy expenditure in mitochondria, is regulated through the 4'-phosphopantetheine...
- The National Science Foundation awarded a $138,000 Project Grant to support research from June 2021 to May 2023 titled "Uncovering the Molecular Mechanisms of Mitochondrial Proteostasis." The grant was awarded under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing knowledge and enhancing understanding of major problems. Funds will support the grantee's research...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
- This federal Project Grant award, valued at $372,880 and issued on May 1, 2025, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project aimed at understanding how cells regulate protein synthesis to maintain homeostasis during cellular stress. The key focus is on investigating the role of the translation initiation factor eIF2 and its phosphorylation in modulating gene...
- This $576,104 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research on the molecular mechanisms underlying transmembrane conduction and signaling in integral membrane proteins. The research aims to define the structural transitions and energy coupling processes that drive and regulate cyclical processes in membrane proteins, with a focus on understanding voltage...
- This $414,159 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the differential stress responses of organelles in eukaryotic cells. The research aims to investigate the molecular mechanisms underlying how cells employ different strategies to respond to nutritional deprivation versus endoplasmic reticulum (ER) stress. The principal investigator at the...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $447,337 to Ball State University to conduct research on the regulator MITONEET and its role in cellular redox homeostasis and signaling. The research aims to investigate how the electronic properties and stability of the MITONEET [2Fe-2S] cluster contribute to the metabolism of sulfur-containing molecules and the...
This $387,500 federal Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research on the molecular mechanisms by which calcium sensing and mitochondrial homeostasis regulate cellular functions, particularly in cell types with high metabolic demands. The research aims to advance understanding of how dysregulated mitochondrial calcium signaling contributes to metabolic stress, cell death, and disease pathology. The grant recipient, Wake Forest University Health Sciences, will conduct this research project over a 5-year period through August 31, 2030. The findings may identify new therapeutic targets for conditions linked to mitochondrial dysfunction.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $387.5k | 8/11/25 |