Project Grant R35GM160196
- The National Institute of General Medical Sciences (NIGMS) awarded a $854,927 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Washington University in Missouri. The grant, effective September 5, 2025 through August 31, 2027, will support research to define the mechanisms of a new pathway for genome stability, known as RNA Damage Induced DNA Breaks (RDIBS). The key objectives are to identify the types of RNA modifications that activate RDIBS, the...
- This $423,890 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859). The grant is being used to support fundamental scientific research and advanced training focused on understanding the mechanisms underlying the survival and uncontrolled proliferation of stem cells with DNA damage, and the influence of surrounding tissues on stem cell behavior during tissue...
- This federal Project Grant award of $617,007 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the molecular mechanisms of DNA double-strand break repair through non-homologous end joining (NHEJ). The research aims to elucidate how DNA ends are held together and coordinated with end processing enzymes to maximize the fidelity of NHEJ and minimize genome alterations. The...
- This federal Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the mechanisms underlying DNA double-strand break repair at Thomas Jefferson University, doing business as Sidney Kimmel Medical College. The research aims to determine the regulatory mechanisms of the multi-protein and multi-step process required to coordinate the repair of DNA...
- This federal Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $303,842 to The Washington University in Missouri to conduct research on the role of the SMC5/6 complex in mitigating mutagenic damage caused by the APOBEC3A enzyme during DNA replication. The project aims to define the impact of APOBEC3A activity on replication fork progression and elucidate the mechanism by which the SMC5/6 complex protects...
- This $516,608 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanisms and regulation of DNA recombination in budding and fission yeast. The key research focus areas are: 1) studying DNA end resection, the critical first step in homologous recombination, within heterochromatin regions, 2) investigating how lagging strand synthesis proceeds during...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms and factors that promote aberrant DNA repair during meiosis, leading to the formation of de novo structural variants. The $380,495 award, with a project period from February 1, 2025 to January 31, 2030, will be performed by the Regents of the University of Michigan. The...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $390,000.00 to The Regents of the University of Colorado (University of Colorado-Denver) to conduct research on the molecular mechanisms of DNA replication during mitosis. The research aims to uncover how cells complete replication of the entire genome before cell division, even when replication is not fully finished in the S phase of...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $445,000 project grant to the Dana-Farber Cancer Institute, Inc. (DFCI) in Boston, Massachusetts. The grant, awarded on January 22, 2025, supports DFCI's research on the molecular mechanisms of DNA double-strand break repair by homologous recombination, a critical process for cell survival and cancer prevention. The project aims to define the complex...
- This Project Grant award, valued at $1,843,775.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to identify and characterize DNA-protein cross-links (DPCs) and their associated repair pathways. The principal investigator at the University of Kansas Center for Research Inc. will use advanced mass spectrometry techniques to profile the molecular signatures of DPCs across...
This federal Project Grant award of $1,943,750.00, awarded on August 8, 2025, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research and advanced training focused on understanding the molecular mechanisms that regulate the mitotic DNA damage response. The project, led by researchers at The Washington University, aims to 1) reveal how ubiquitinated histone H2A acts as a molecular switch between interphase and mitotic DNA repair programs, and 2) investigate the regulation of DNA end resection during mitosis and its impact on DNA repair pathway activation. This research will help unravel the complex regulatory processes governing the cell's response to DNA double-strand breaks during mitosis, with potential implications for improving genome stability and disease treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 8/6/25 |