Project Grant R35GM160182
- This federal Project Grant award of $420,984 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand how viruses sense and respond to host cell cues in real-time to coordinate their life cycle. The key focus is on studying how host-derived post-translational modifications of viral proteins act as molecular biosensors to enable viruses to adapt to the intracellular environment....
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $400,530 Project Grant to the Rector & Visitors of the University of Virginia (UVA) on June 1, 2025. The grant supports UVA's research to develop next-generation nanodisc tools that can characterize membrane protein-lipid interactions essential for understanding cell-cell interactions and communication. Specifically, the research will focus on...
- This federal Project Grant award of $416,398 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental scientific research on the regulation of neutral lipid metabolism in eukaryotes. The research program at Texas A&M AgriLife Research, a component of the Texas A&M University System, aims to elucidate the underlying mechanisms controlling the enzymatic activity of acyltransferases...
- This Project Grant award of $440,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on two key research areas: Developing a quantitative understanding of the processes involved when contractile injection systems (e.g. phage tails, tailocins, Type VI secretion systems) breach bacterial cell envelopes. This knowledge will be applied to the design and retargeting of R-type pyocins...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training, provides $585,000.00 to the University of Texas at Dallas to pursue innovative strategies and platforms for (a) discovering 'natural product'-like macrocyclic peptides as modulators of biomolecular interactions, and (b) developing biocatalytic strategies for asymmetric synthesis via 'new-to-nature' chemistries. The project builds upon prior...
- This federal Project Grant award of $574,000, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental scientific research and advanced training across diverse areas of biomedical science. The award, with a performance period from May 1, 2025 to Feb 28, 2030, will fund the University of Texas Southwestern Medical Center's research project to understand the general working principles of...
- This Project Grant award for $2,158,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Rutgers, The State University of New Jersey to investigate how the host metabolism impacts immune responses during bacterial infections. The research aims to deepen the mechanistic understanding of how host metabolic activities influence immune cell activation and function, with a focus...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research on manipulating the DNA damage response and proteome on viral genomes during herpes simplex virus (HSV) infection. The $651,832 award, with a project period from November 2024 to October 2029, will enable researchers at The Children's Hospital of Philadelphia to conduct a multi-modal proteomic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $626,423 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Texas Medical Branch at Galveston (UTMB). The funding will support research to explore the dependence of arenaviruses on the metabolism of the monosaccharides D-glucose and D-mannose, with the goal of developing carbohydrate antimetabolite compounds as potential pan-arenavirus therapeutics. Specifically,...
- The University of Texas Southwestern Medical Center (UT Southwestern) received a $125,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the molecular mechanisms underlying purine salvage regulation in response to suppressed oxidative phosphorylation (OXPHOS) in macrophages. The overarching objective is to elucidate how OXPHOS suppression potentiates purine...
The National Institute of General Medical Sciences (NIGMS) awarded a $429,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Texas at Dallas (UTD). The grant, effective August 1, 2025 through July 31, 2030, will support research to define the novel cellular mechanisms by which cells in the latent and lytic stages of herpesvirus infection control metabolic regulation. The objective is to conduct an integrative analysis of the metabolic, lipid, and transcriptional profiles that distinguish cell subpopulations during the progression of viral infections. The research aims to address fundamental gaps in knowledge regarding the molecular drivers of metabolic rewiring in response to viral infection and its impact on cellular homeostasis and viability.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 7/31/25 |