Project Grant R35GM159976
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
- This federal Project Grant award of $350,275.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), with a performance period from July 1, 2025 to June 30, 2030. The grant supports a research project at the University of New Mexico (UNM) Health Sciences Center that aims to investigate the molecular mechanisms by which extracellular glucose levels regulate cell mechanics and function. The research...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $370,190 to San Diego State University Foundation to conduct research on the molecular mechanisms of viral nucleocapsid self-assembly and disassembly. The research aims to enhance fundamental understanding of these essential steps in the replication of RNA-packaging viruses, which could inform the development of new...
- This $640,500 project grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support research to investigate the role of microtubule allostery and mimicry in regulating tubulin post-translational modifications. The project, conducted by the University of New Mexico (UNM) Health Sciences Center, aims to deepen the understanding of how microtubule conformational states and interactions with...
- This federal Project Grant award of $420,984 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand how viruses sense and respond to host cell cues in real-time to coordinate their life cycle. The key focus is on studying how host-derived post-translational modifications of viral proteins act as molecular biosensors to enable viruses to adapt to the intracellular environment....
- The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $355,584 Project Grant to the New Mexico Institute of Mining and Technology (New Mexico Tech) on August 18, 2023. This funding will support research to determine the biochemical basis and functional implications of the interaction between the proteins XRN2 and DDX23, and explore their cooperative role in regulating RNA-DNA hybrid structures...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $447,548 to Brigham Young University to investigate the molecular mechanism by which the SARS-CoV-2 virus hijacks the host cell chaperone system to replicate itself. The research aims to thoroughly test the hypothesis that the SARS-CoV-2 non-structural protein 12 (NSP12), the catalytic subunit of the RNA polymerase, is...
- This Project Grant award, ID R35GM156443, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $419,375 award, spanning January 1, 2025 to November 30, 2029, supports research at the University of New Mexico Health Sciences Center (UNM HSC) to define the functional dynamics of multidomain redox enzymes, with a focus on nitric oxide synthase (NOS) enzymes. The research aims to gain a comprehensive...
- This $582,618 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to determine the mechanisms by which RNA N6-methyladenosine (m6A) and pseudouridine (Ψ) modifications modulate SARS-CoV-2 replication, gene expression, immunity, and pathogenesis. Key activities include using CRISPR-Cas9 to knock out host m6A methyltransferases and pseudouridine synthases in human bronchial epithelial cell...
This federal Project Grant award, valued at $2,094,250 and administered by the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 (Biomedical Research and Research Training), supports research at the University of New Mexico (UNM) into the interactions between the methionine cycle and coronavirus RNA capping mechanisms. The research aims to elucidate the spatiotemporal regulation and quaternary structures of enzyme complexes involved in the methionine cycle, which is essential for providing metabolites required for coronavirus RNA capping. This is a critical process that prevents triggering the host cell's innate immune response during coronavirus infection. The project will investigate how coronavirus replication and capping enzymes may modify host metabolic assemblies to produce the necessary metabolites. Advancing the understanding of these mechanisms could reveal novel drug targets to inhibit viral replication and address current and future coronavirus outbreaks. The award period runs from September 1, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.1m | 8/14/25 |