The National Institute of General Medical Sciences (NIGMS) awarded a $388,750 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Washington to conduct research on the biophysical mechanisms underlying Drosophila renal tubule morphogenesis. The research program aims to understand how cells coordinate to build and sculpt the complex 3D architecture of epithelial tubular structures, which is essential for organ function. The project will focus on...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $440,454 to The Washington University to study epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The project will investigate how epithelial cells sense and respond to extracellular matrix properties, force transmission, and nuclear mechanosensing in the context of processes like wound...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $393,093 to The Trustees of Columbia University in the City of New York to uncover the interplay between gene expression, cell morphometrics, and tissue-level mechanics during embryonic development. The research aims to develop an integrative, statistical machine learning framework for 4D mammalian development, leveraging...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $435,875 in funding to Vanderbilt University to conduct research on the mechanisms of epithelial cell behavior and polarity establishment. The research aims to enhance the understanding of epithelial cell polarization and behaviors in tissue morphogenesis, focusing on probing the molecular mechanisms of apical...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $490,841.00 to Trustees of Dartmouth College to conduct research on the mechanical coordination and mechano-biochemical feedback mechanisms underlying epithelial folding during embryogenesis. The research aims to elucidate the regulatory networks and physical principles that govern how tissues generate, sense, and...
This Project Grant award for $509,982.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research conducted by the University of Maryland, College Park to unravel the fundamental mechanisms governing cell-cell communication and signal exchange during animal development. The research aims to characterize a novel "direct delivery" mechanism of extracellular signal...
The National Institute of General Medical Sciences (NIGMS) awarded a $389,211 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Massachusetts (UMass) Amherst. The grant, which runs from July 2024 to June 2029, will fund research to investigate the biophysical and molecular mechanisms underlying a novel process of "meso-scale gap closure" in tissues undergoing epithelial-mesenchymal transition. The research aims to...
This National Science Foundation Project Grant award of $250,000 supports research at Louisiana State University from May 1, 2022 to April 30, 2025 under the Integrative Activities program. The research aims to define signaling pathways that control cytoskeletal networks during epithelial tube formation using the developing salivary glands of Drosophila melanogaster. Specifically, the project will identify and characterize unidentified salivary gland G protein-coupled receptors that reorganize...
This $145,642 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a research project focused on quantifying the contribution of supracellular actomyosin networks during mouse neural tube closure. The project aims to: 1) Quantify key features of the actomyosin networks in the mouse neural tube, including protein levels, actomyosin cable orientation, and cellular morphologies, through...
This Project Grant award for $479,487 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at The Johns Hopkins University to investigate how key physical cues, such as extracellular fluid viscosity, microenvironmental stiffness, and cellular confinement, regulate cell migration and function. The research aims to develop a comprehensive understanding of how these...