Project Grant R35GM159832
- This federal Project Grant award of $404,058.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project focused on investigating the mechanisms that regulate the formation of crossovers on meiotic chromosomes. The research aims to use single-molecule imaging techniques to understand how the dynamics of proteins that control crossover formation create coordinated patterns along...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- This federal Project Grant award of $3,101,237.00 was provided by the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, under the Aging Research federal grant program (CFDA 93.866). The funding supports a research project investigating the mechanisms linking persistent DNA damage to immune responses and hematopoietic stem and progenitor cell function in the context of aging and DNA repair deficiency. Key objectives of the project include: 1) elucidating...
- This federal Project Grant award of $190,278.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the role of transposable elements in septic immune aging. The research aims to 1) examine the dynamics of transposable element de-repression as a function of age and sepsis, and 2) employ machine learning to quantify immune aging and identify specific transposable elements...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms and factors that promote aberrant DNA repair during meiosis, leading to the formation of de novo structural variants. The $380,495 award, with a project period from February 1, 2025 to January 31, 2030, will be performed by the Regents of the University of Michigan. The...
- This $423,890 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859). The grant is being used to support fundamental scientific research and advanced training focused on understanding the mechanisms underlying the survival and uncontrolled proliferation of stem cells with DNA damage, and the influence of surrounding tissues on stem cell behavior during tissue...
- This federal Project Grant award of $188,627, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), funds the development of tools to measure post-translational modification enzyme activity, with a focus on kinases. The project aims to (1) build understanding of kinase-substrate interactions using techniques like in vitro phosphoproteomics, novel substrate design, and computational methods, and (2) develop...
- The University of Massachusetts Medical School (UMass Medical) was awarded a $1,507,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct a study on spatial single-cell analysis of somatic mutations in the human brain during aging and neurodegeneration. The goal is to develop and apply new single-cell whole-genome sequencing methods to study somatic mutations in neurons from late-stage Alzheimer's disease and...
- This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $387,500 Project Grant to The Johns Hopkins University on May 1, 2025. The funding supports a research program that systematically investigates the roles of conserved microRNAs during animal development. The research leverages the experimental system provided by C. elegans, utilizing state-of-the-art molecular biology and genetics approaches. The...
This federal Project Grant award of $423,500.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the Regents of the University of Minnesota. The grant supports a 5-year research project focused on quantitatively exploring somatic mutation burdens in normal, non-cancerous mouse tissues across different life stages. The project aims to utilize cutting-edge DNA sequencing technologies and computational analyses to identify mutational signatures and clusters, in order to infer molecular mechanisms and risk factors related to somatic mutations. This research is intended to address critical knowledge gaps and challenges in understanding the role of somatic mutations in functional decline and aging. The award commences on August 13, 2025 and is scheduled for completion on May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $423.5k | 8/13/25 |