Project Grant R35GM159748
- This Project Grant award, valued at $379,394.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project investigating the mechanisms by which human cells detect and respond to oxidative stress, with a focus on understanding the dose-dependent activation of key stress response proteins. The research aims to uncover how dynamic stress response pathways influence cell...
- This Project Grant award of $562,320 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Oakland University to determine the role of pseudouridine synthases in regulating autophagy, a critical cellular process for maintaining health and survival under stress conditions. The research aims to elucidate the molecular mechanisms underlying cellular responses necessary for survival, which is a...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $407,562 to the University of Denver to conduct research on the molecular mechanisms of lysosome remodeling in response to cellular stress. The 5-year project, starting September 1, 2025, aims to characterize the degradation pathways of vacuole membrane proteins and investigate the transcriptional regulation of...
- The federal Project Grant award of $420,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to identify the molecular mechanisms of mitochondrial dysfunction in pathological stress conditions. The primary objective is to investigate the processes of oxidative phosphorylation and mitochondrial membrane potential disruption, which can lead to cell death and tissue damage in various diseases....
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $828,803 aims to better understand how cells determine their fate when under stress in the endoplasmic reticulum (ER), the cell's power plant that produces and folds proteins. The research project at William Marsh Rice University develops new tools to investigate how genes behave in real-time and create systems to help cells better manage protein production under stress. The...
- This federal Project Grant award, valued at $372,880 and issued on May 1, 2025, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project aimed at understanding how cells regulate protein synthesis to maintain homeostasis during cellular stress. The key focus is on investigating the role of the translation initiation factor eIF2 and its phosphorylation in modulating gene...
- This Project Grant award for $316,368.00 was provided by the National Institute of General Medical Sciences (NIGMS), which administers the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The grant will fund research to understand the mechanisms of metabolic adaptation in cells, focusing on the autophagy and cytochrome P450 pathways. The research aims to elucidate how these pathways respond to nutrient scarcity and chemical stressors, using advanced genomics,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $248,975 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University on August 28, 2025. The project, titled "Stress Response Signaling as a Metabolic Sensor in Reproduction," aims to examine how nutrient sensing alters reproductive capacity via the integrated stress response (ISR) signaling pathway and steroid hormones in the Drosophila model organism. The research...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
This $414,159 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the differential stress responses of organelles in eukaryotic cells. The research aims to investigate the molecular mechanisms underlying how cells employ different strategies to respond to nutritional deprivation versus endoplasmic reticulum (ER) stress. The principal investigator at the University of Rochester will integrate structural prediction with genetic and cellular assays to identify selective autophagy receptors and use multi-omics approaches to examine potential crosstalk between organelles during starvation. The project also examines how cells reorganize multiple organelles to mitigate ER stress, with potential implications for understanding disease pathology and developing new diagnostic and therapeutic strategies. The research will be conducted over a 5-year period from September 2025 to July 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $414.2k | 8/27/25 |