Project Grant R35GM159745
- The University of California, San Diego will receive $1.5 million over five years from the National Science Foundation under its Biological Sciences program (CFDA 47.074) to conduct a project titled "CHEMOENZYMATIC CONSTRUCTION OF A PROGRAMMABLE SYNTHETIC ENDOPLASMIC RETICULUM." From August 2021 through July 2026, UCSD researchers will work to develop new techniques for engineering the endoplasmic reticulum, a cellular organelle, using enzymatic and chemical methods. The Biological...
- The National Institute of General Medical Sciences (NIGMS) awarded a $376,498 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) for a 5-year research program from August 1, 2025 to July 31, 2030. The research will focus on developing new active genetic systems that can function in both germline and somatic cell contexts. This includes exploring the use of CRISPR-based gene drive systems to potentially...
- The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...
- This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of haloperoxidase enzymes for new applications in chemical synthesis, particularly for halogenation reactions. The $2,021,315 award, effective from September 1, 2025 to August 31, 2029, will enable researchers at Emory University to expand the synthetic capabilities of the vanadium-dependent...
- The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) in the amount of $380,725 on May 5, 2025. The grant will support research to understand the molecular drivers of viral receptor-binding protein (RBP) evolution, including how mutations allow RBPs to gain new functions and the factors that constrain their evolution and enhance their...
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- This $700,000 Project Grant was awarded by the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program to the University of California, San Diego (UCSD) on August 1, 2025. The grant funds a 3-year research project to investigate how bacteria use RNA "switches" called riboswitches to regulate the import and export of metal ions, which are important for cellular function but can be toxic in excess. Specifically, the project aims to map the co-transcriptional...
- This federal Project Grant award of $151,040.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley. The funding supports research to develop supramolecular photocatalysts that can enable novel photochemical reactions to produce oxygen- and nitrogen-containing heterocycles in a highly selective...
- The University of California, San Diego (UCSD) was awarded a $1,031,651 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant, awarded on February 1, 2025, aims to optimize the in vitro production, cryopreservation, and biobanking of "cargocytes" - a novel therapeutic delivery system designed to transport therapeutic...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
The University of California, San Diego (UCSD) received a $423,975 Project Grant under the National Institute of General Medical Sciences' (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) to conduct research on identifying and characterizing a new family of halogenase enzymes. The project aims to develop biocatalytic methods using these novel halogenases to selectively install halogen atoms onto organic compounds in an environmentally-friendly manner, which has significant implications for medicinal chemistry applications. The 5-year project period runs from September 1, 2025 through August 31, 2030 and will leverage UCSD's expertise in bioinformatics, natural product biosynthesis, and enzymology to advance the discovery and application of these unique halogenase enzymes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $424.0k | 8/11/25 |