This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $387,500.00 to investigate the evolutionary constraints on regulatory RNA. The research aims to understand how concepts developed for protein evolution, such as robustness, plasticity, promiscuity, and epistasis, apply to the evolution of RNA regulators. Key aspects include mapping the relationships between RNA sequence, regulatory functionality, and organism fitness, both in vitro and within mouse infection models. The research will enable connecting biophysical models of RNA folding with functional regulatory parameters, and inform the development of RNA-targeting therapeutics and synthetic RNA regulatory systems for biotechnological applications. The award has an effective date of July 1, 2025 and a projected completion date of May 31, 2030. The principal investigator and lead institution for this award is Trustees of Boston College, a private Jesuit Catholic research university.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $387.5k | 6/26/25 |