Project Grant R35GM158394
- This Project Grant award of $210,090.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The award supports a research and training program at the University of Oklahoma Health Sciences Center (OUHSC) focused on increasing the number of graduate students in biomedical sciences and implementing improved training mechanisms. Key elements of the program include modernizing the...
- This $415,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research on the structure and function of G protein-coupled receptors (GPCRs). The research aims to bridge gaps in understanding the complexity of GPCR signaling pathways and their promiscuous activation of diverse G protein subfamilies. The five-year project, awarded to Sanford Research, a nonprofit...
- This federal Project Grant award of $390,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the structural dynamics of G protein-coupled receptor (GPCR) oligomerization and its impact on cellular localization and signaling. The 5-year award, effective August 1, 2025, will fund investigations into the complexes formed between GPCRs, G proteins, β-arrestins, and GPCR kinases,...
- This federal Project Grant award for $2,463,036, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the establishment of the Center for Genomic Regulation (CGR) at the Oklahoma Medical Research Foundation (OMRF). The goal of the CGR is to build a focused research community that performs collaborative research and effective training in the area of genomic regulation, which includes studies...
- This $694,875 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Boston University Medical Campus to advance the understanding of G protein-coupled receptor (GPCR) and heterotrimeric G protein signaling plasticity. The research aims to define the physiological implications of non-GPCR activation of G proteins and develop innovative tools to measure G protein activity....
- This $445,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by the Beckman Research Institute of the City of Hope on the emergent role of allostery on the function of G protein-coupled receptors (GPCRs) and trimeric G proteins. The key objectives of this 5-year project, which began in February 2025, are to: 1) Dissect the structural basis of allosteric modulation by...
- The National Institute of General Medical Sciences (NIGMS) awarded a $377,123 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RF SUNY) on September 1, 2025. The grant supports a research program aimed at providing structural and mechanistic insights into the ligand specificity of A1-adrenergic receptors (A1-ARs) through the use of cryo-electron microscopy, biochemical, and cellular studies....
- This federal Project Grant award of $574,000, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental scientific research and advanced training across diverse areas of biomedical science. The award, with a performance period from May 1, 2025 to Feb 28, 2030, will fund the University of Texas Southwestern Medical Center's research project to understand the general working principles of...
- This Project Grant award of $407,750.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the allosteric mechanisms of two key enzyme systems - glutamate racemases (GR) and executioner caspases-7 (C7). These enzymes are validated drug targets for antimicrobials and Parkinson's/inflammatory diseases, respectively. The research employs experimental and computational approaches...
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
The University of Oklahoma Health Sciences Center (OUHSC) was awarded a $389,310 Project Grant from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) effective September 1, 2025 through July 31, 2030. The grant supports research to study how receptor activity-modifying proteins (RAMPs) determine ligand selectivity and promote cAMP signaling for class B G protein-coupled receptors (GPCRs), which are drug targets for conditions like osteoporosis, diabetes, obesity, migraine, and cardiovascular/lymphatic disorders. The research utilizes biochemistry, pharmacology, and structural biology approaches to advance the understanding of peptide binding, receptor activation, and G protein coupling for this complex GPCR signaling system. The findings are expected to enable the engineering of novel peptide antagonists and agonists with useful therapeutic properties.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $389.3k | 8/11/25 |