Project Grant R35GM158384
- This federal Project Grant award of $1,968,575.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on developing computational approaches and machine learning methods to predict DNA-binding specificities for transcription factor proteins and the functional effects of genetic variants within proteins. The overarching goal is to gain a predictive understanding of proteins, their interactions,...
- This federal Project Grant award of $667,480.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The award supports fundamental scientific research and advanced training focused on understanding the regulation of genome expression by chromatin and how mutations in chromatin proteins contribute to oncogenesis. The research aims to provide new insights...
- This Project Grant award of $568,113 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research into variant chromatin structures and their functions. The research aims to investigate how these specialized chromatin particles, including the histone variant H2A.Z, are targeted to specific genomic sites and how they modulate transcription. The project will leverage a novel in vitro transcription...
- The federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 - Biomedical Research and Research Training is supporting a $3,125,817 research project at New York University School of Medicine titled "Decoding Positional Epigenetic Memory." The project aims to decipher how stable positional identity is generated through the regulation of HOX gene expression, which is crucial for proper cell differentiation and disease...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This federal Project Grant award for $426,250.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the Oklahoma Medical Research Foundation (OMRF). The grant supports two research projects focused on understanding how different chromatin regulator complexes influence facultative heterochromatin balance and organization. The first project examines the opposing roles of three SWTICH/SNAF chromatin...
- This federal Project Grant award of $156,980 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "Mechanisms of SAGA Regulation by Histone Crosstalk". The project aims to study the acetylation activity of the SAGA transcriptional co-activator complex on mono- and di-nucleosomes with biologically relevant post-translational modifications. This research will...
- The National Institute of General Medical Sciences (NIGMS) awarded a $249,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RFSUNY), doing business as Stony Brook University. The grant will fund a 3-year research project from September 1, 2025 to August 31, 2028 to study the "Dynamic Mechanisms of Transcriptional Coactivator Function in Notch Signaling." The research aims to...
- This federal Project Grant award for $678,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the molecular mechanisms governing the assembly of eukaryotic ribosomes. The research aims to define the co-transcriptional assembly events and transitions towards stable post-transcriptional nucleolar assembly intermediates of ribosomal subunits, leveraging advanced...
- This federal Project Grant award of $222,708 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanistic basis of individual and clustered enhancers in human cells. The goal is to elucidate the molecular mechanisms underlying long-range enhancer-promoter interactions and the role of enhancer clusters in regulating gene expression, with a focus on the MYC locus. The...
This federal Project Grant award of $2,203,340.00, awarded on September 20, 2025 by the National Institute of General Medical Sciences (NIGMS), is part of the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research to define the mechanistic rules governing how transcription factors (TFs) bind to chromosomal DNA within compacted chromatin. The goal is to systematically dissect the factors required for initial and sustained TF binding to chromatin, including the role of nucleosome positioning, histone modifications, and chromatin remodeling. The research will combine in vitro and in-cell assays to address three key questions: 1) How do TFs recognize their binding sites within a nucleosome? 2) How do histone modifications and nucleosome positioning regulate TF binding? 3) How does chromatin organization regulate TF binding and function? The awardee, The Research Foundation For The State University Of New York, will conduct this research to close critical knowledge gaps in understanding TF-chromatin interactions, which are essential for fundamental biological processes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.2m | 9/19/25 |