Project Grant K99GM159062
- The federal Project Grant award titled "Structure, Function, and Dynamics of Non-Canonical Stress Granules" was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $445,873 award to Worcester Polytechnic Institute (WPI) supports research to understand the composition, structure, and function of non-canonical stress granules, which are cytoplasmic condensates that form in response to...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This federal Project Grant award, valued at $372,880 and issued on May 1, 2025, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project aimed at understanding how cells regulate protein synthesis to maintain homeostasis during cellular stress. The key focus is on investigating the role of the translation initiation factor eIF2 and its phosphorylation in modulating gene...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- This federal Project Grant award, valued at $375,430.00 and awarded on February 1, 2025, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the regulation of germ granules, a type of RNA condensate, by RNA helicases and the impact of condensation on RNA helicase activity. The research aims to establish a framework for understanding the regulation of RNA...
- This federal Project Grant award for $440,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research program at Northwestern University that investigates how RNA modifications, known as the epitranscriptome, regulate the translation of mRNA into proteins and how this interplay affects cell responses to stress. The research aims to fill gaps in understanding of how...
- This federal Project Grant award for $678,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the molecular mechanisms governing the assembly of eukaryotic ribosomes. The research aims to define the co-transcriptional assembly events and transitions towards stable post-transcriptional nucleolar assembly intermediates of ribosomal subunits, leveraging advanced...
- This federal Project Grant award of $2,053,480.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The project aims to develop a novel framework for analyzing pathway interactions and pathway-phenotype associations in bulk and single-cell RNA sequencing (RNA-seq) studies. The key products or...
- This Project Grant award of $114,300.00 from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) supports The Regents of the University of Colorado, doing business as the University of Colorado-Denver, in conducting high-throughput experimental and computational research to identify RNA elements that regulate trafficking to midbodies. The research aims to use massively parallel reporter assays, single-molecule imaging, and machine learning...
- This Project Grant award, valued at $379,394.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project investigating the mechanisms by which human cells detect and respond to oxidative stress, with a focus on understanding the dose-dependent activation of key stress response proteins. The research aims to uncover how dynamic stress response pathways influence cell...
This federal Project Grant award of $125,000 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of Colorado. The project, titled "Intermolecular RNA-RNA Interactions in Stress Granule Regulation and Disease," aims to determine how the stress granule scaffolding protein G3BP1 facilitates the formation of intermolecular RNA-RNA interactions, identify the RNA elements involved, and investigate how the cell mitigates stable RNA-RNA interactions during normal stress response and recovery. The research will employ biochemical, transcriptomic, and high-throughput genetic screening approaches to advance the understanding of stress granule organization and function, with the goal of informing the development of treatments for diseases associated with chronic stress granule formation, such as aging, neurodegenerative disorders, and cancer. The award period runs from Sep 1, 2025 to Aug 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 8/29/25 |