Project Grant R35GM158247
- This Project Grant award of $384,896.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop novel peptide-based biomaterials that can directly modulate cell and tissue responses. The goal is to create advanced biomodulatory materials, such as self-adjuvanting vaccines, anti-inflammatory therapeutics, cell-targeted cancer therapies, and bone regenerative products, to address challenges in...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the discovery and engineering of ribosomally synthesized and post-translationally modified peptides (RiPPs). The $558,651 award, with a performance period from August 1, 2025 to July 31, 2030, will fund research conducted by Vanderbilt University to leverage RiPP biosynthesis for various biomedical...
- This Project Grant award of $249,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is to support research at Duke University to expand the capabilities of enzymes beyond their natural functions for synthesizing medicinally important chemical compounds. The key products or services to be delivered include engineering heme enzymes and methionine sulfoxide reductases to catalyze aminations and oxidations,...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $444,125.00 to the Rector & Visitors of the University of Virginia (UVA) to conduct research on the molecular mechanisms of protein sorting and localization to organelles. The research aims to uncover how nascent polypeptide chains are processed and folded by chaperones during transport across the endoplasmic...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $658,165.00 in funding to Triad National Security, LLC to conduct research on the effects of ions on mRNA elements, ribosomes, and antibiotic-RNA interactions. The project aims to improve the fundamental understanding of ribosome function and the mechanisms underlying mRNA translation, with a focus on the bacterial...
- This federal Project Grant award of $386,617 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop safer and more efficient chemical methods for the synthesis of complex, fluorinated, and highly functional pharmaceutical compounds. The key research areas encompass: (1) electromicellar catalysis for the formation of fluorinated heterocycles, allenes, and reactive intermediates; (2) enantioselective...
- This federal Project Grant award of $654,950.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to establish a unified framework for generating oligonucleotide-based receptors (aptamers) to detect a variety of small molecule targets that are difficult to isolate using standard protocols. The research, conducted by The Trustees of Columbia University in the City of New York, will address two...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $147,656 to the University of North Carolina at Chapel Hill (UNC-CH) to support research on modular chimeric tRNA synthetases and their application in mRNA display technology. The goal is to develop a "plug-and-play" system for incorporating diverse non-canonical amino acids into macrocyclic peptide therapeutics, which can...
- This federal Project Grant award of $1,968,575.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on developing computational approaches and machine learning methods to predict DNA-binding specificities for transcription factor proteins and the functional effects of genetic variants within proteins. The overarching goal is to gain a predictive understanding of proteins, their interactions,...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $400,530 Project Grant to the Rector & Visitors of the University of Virginia (UVA) on June 1, 2025. The grant supports UVA's research to develop next-generation nanodisc tools that can characterize membrane protein-lipid interactions essential for understanding cell-cell interactions and communication. Specifically, the research will focus on...
This $378,899.00 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to expand the genetic code and improve the drug-likeness of hits generated through mRNA display technology. The key objectives are: Leveraging hyperaccurate ribosomes and engineered tRNAs to move closer to a one codon-one amino acid paradigm, thereby enhancing the diversity of macrocyclic peptides that can be screened. Incorporating unnatural base pairs to further increase the potential monomer diversity within mRNA display libraries. Developing a prioritization strategy for selecting the most promising monomers to incorporate into macrocyclic peptide leads. The award was made on August 1, 2025 to Virginia Commonwealth University, a public research university, and the project is set to be completed by May 31, 2030. This work has the potential to significantly expand the druggable target space by improving the drug-likeness of peptide-based hits identified through mRNA display technology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $378.9k | 8/1/25 |