Function, evolution and engineering of proteins

Active Project Grant Awarded Last action

Award ID
R35GM158173
Recipient
Awarding agency
Obligated
$723,904

Award facts

Assistance listing
93.859 Biomedical Research and Research Training
Completion date 24% complete
Place of performance
Berkeley, CA 94720, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The sequence-function landscape of a protein is the connection of genotype and phenotype at a molecular level. Although abstract, this concept has many real-world applications. Mapping and predicting this space would improve our basic science understanding of macromolecular function in the cell, clarify the role of genetic variation in causing disease, and lead to our ability to design biological therapeutics with improved potency and specificity. The goal of our work is to develop experimental methods to systematically explore the mutational landscape of biomedically relevant proteins such as crispr-CAS genome editing enzymes. A related aspect of our work is to create new types of assays that yield robust measurements of real biochemical parameters, rather than relative measurements which are typically measured out of convenience. In the long term, our goal is to couple this data, mechanistic studies, and machine learning tools to develop state of the art methods for predicting and engineering protein function.

Transactions

Action Obligated Date
Amendment $361,952
Original award $361,952

Quick answers

Who received award R35GM158173?

R35GM158173 was awarded to The Regents Of The University Of California by National Institute of General Medical Sciences (National Institutes of Health) on September 1, 2025.

How much is award R35GM158173 worth?

$723,904 has been obligated on R35GM158173.

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