Project Grant R35GM158083
- The National Institute of General Medical Sciences (NIGMS) awarded a $125,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Rector & Visitors of the University of Virginia (UVA) to study the evolution and mechanisms of pathogen avoidance behavior in the nematode host, Caenorhabditis elegans, and its virulent bacterial pathogen, Serratia marcescens. The research aims to examine the interplay between innate and learned pathogen avoidance...
- This National Science Foundation (NSF) Biological Sciences Program (CFDA 47.074) grant award to the University of California, Davis (UC Davis) aims to advance the understanding of how plants recognize and respond to infection by plant parasitic nematodes, one of the most destructive plant pathogens causing an estimated $78 billion in global annual losses. The $796,385 project, running from July 1, 2023 to June 30, 2027, will identify nematode-derived molecules that activate plant innate immunity...
- The National Institute of General Medical Sciences (NIGMS) awarded a $376,498 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) for a 5-year research program from August 1, 2025 to July 31, 2030. The research will focus on developing new active genetic systems that can function in both germline and somatic cell contexts. This includes exploring the use of CRISPR-based gene drive systems to potentially...
- The National Science Foundation Division of Integrative Organismal Systems awarded a $499,872 Project Grant to the California Institute of Technology (Caltech) from August 15, 2021 to July 31, 2025. The grant supports research under the Biological Sciences program (CFDA 47.074) to develop Functional Genomic Tools for Parasitic Nematodes and Their Bacterial Symbionts. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research....
- The University of California, Davis received a $435,769 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). This 5-year grant, awarded on September 1, 2025, supports the university's research efforts to uncover the physical principles that define the function of the cellular glycocalyx. The key objectives are to develop novel imaging tools, computational models, and genetic engineering...
- This $300,122 National Science Foundation project grant supports research titled "Collaborative Research: EDGE FGT: Functional Genomic Tools for Parasitic Nematodes and Their Bacterial Symbionts." Awarded on August 15, 2021 to the University of California, Riverside for the period through July 31, 2025, the grant funds basic biological research under the NSF's Biological Sciences program (CFDA 47.074). Specifically, the University of California, Riverside will develop new functional...
- This $748,123 U.S. Department of Agriculture (USDA) Agriculture and Food Research Initiative (AFRI) Project Grant awarded to the University of California, Davis (UC Davis) aims to elucidate the genetic mechanisms and identify factors contributing to root-knot nematode outbreaks in resistant tomato plants. The project will use comparative genomics to investigate the fitness costs associated with resistance-breaking nematode populations, and develop rapid diagnostic tools to identify resistant...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $769,201 to the University of Massachusetts Medical School to research and develop novel treatments for parasitic gastrointestinal nematode (GIN) infections. The project aims to discover optimal combinations of Bacillus thuringiensis (Bt) crystal proteins and small molecule anthelmintic drugs to...
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,399,125 Project Grant to The Regents of the University of California, doing business as the University of California, Berkeley, under the NIGMS Biomedical Research and Research Training program (CFDA 93.859). The grant aims to decode the molecular processes that regulate circadian rhythms in malaria parasites and discover how disrupting their regulatory networks impacts malaria pathogenesis and transmission. The project will...
- This $198,724 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by the University of California, Santa Cruz on the functional genetic basis of the symbiotic relationship between the Wolbachia bacteria and Drosophila fruit flies. The overarching goal is to develop a robust understanding of the evolutionary genetics and functional mechanisms underlying this host-symbiont...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $391,364 Project Grant to the University of California, Davis (UC Davis). The grant, with a performance period from September 4, 2025 to August 31, 2030, aims to characterize the vitamin B metabolism pathways in parasitic nematodes and their hosts. The project seeks to identify which vitamin B components the nematodes obtain from their hosts versus synthesize themselves, and how this balance affects the parasites' growth and reproduction. This research could lead to the development of novel control strategies targeting specific enzymes in the nematodes' vitamin B pathways, which are typically absent in animals. Additionally, the project will develop functional genomic tools for parasitic nematodes, providing optimized heritable genome editing capabilities. The goal is to deepen the understanding of the energy and nutritional needs of these parasites, with potential implications for improving strategies to combat nematode infections that affect approximately 1.5 billion people worldwide.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $391.4k | 9/2/25 |