This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will provide $392,500.00 from August 1, 2024 through June 30, 2029 to Rutgers, The State University of New Jersey to conduct research on the homeostasis of one-carbon metabolism and its role in supporting epigenetic methylation. The key objectives of this project are to: 1) quantify S-adenosyl-methionine (SAM) production and...
The National Institute of General Medical Sciences (NIGMS) awarded a $411,250 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Trustees of Columbia University in the City of New York to investigate how changes in intracellular and extracellular metabolites, particularly polyamines, affect chromatin biology and cell fate. The 5-year grant, effective July 15, 2024, will enable the research team to explore the role of polyamines in regulating chromatin accessibility,...
This Project Grant award of $578,254 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanisms regulating species-specific developmental rates in mammalian embryos. The project aims to leverage an in vitro system that recapitulates the difference in developmental rate between mouse and human cells to understand why basal metabolic rates are elevated in mouse cells, how metabolism...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting research on epigenetic regulation of transcriptional programming at Brigham & Women's Hospital. The $2,720,800 award from July 2024 to May 2029 will fund investigations into how chromatin regulators and transcription factors collaborate to enable the remarkable developmental transitions of a single fertilized egg into a...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to identify and characterize key mechanisms controlling cellular metabolism. The $466,125 award, effective June 1, 2025 through May 31, 2030, will enable researchers at New York University School of Medicine to develop cell and mouse models to study the physiological importance of metabolite sensing...
This $361,454 federal Project Grant award was issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The grant supports research to elucidate the molecular mechanisms underlying circadian clock period compensation in fungi and mammals. The key objectives are to: 1) Define cellular effectors and metabolic variables controlling circadian oscillations in fungi, and test for conservation in human cells, and 2)...
The National Institute of General Medical Sciences (NIGMS) awarded a $421,600 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Morgridge Institute for Research, Inc. to investigate the interplay of genetic and environmental factors that influence human cell fitness. The project aims to: 1) understand context-dependent genetic contributions to cell growth, 2) examine physiologic nutrient dependencies, and 3) delineate environmental contributions to T cell fitness....
This federal Project Grant award, valued at $423,750.00 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate the spatiotemporal regulation of epigenetic silencing through macromolecular interactions. The research aims to elucidate the mechanisms governing the dynamic control of histone H3 lysine 27 trimethylation (H3K27me3), which is critical for regulating gene...
This federal Project Grant award, issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), provides $2,586,600.00 to the Van Andel Research Institute (VAI) in Grand Rapids, Michigan. The funding supports research to define the regulatory and pathologic mechanisms that connect ubiquitin signaling to the epigenetic inheritance of DNA methylation. The goals are to understand how, when, and where DNA methylation...
The federal Project Grant award R35GM155301, valued at $246,500.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will fund research to investigate the structure, function, and regulation of two mRNA methyltransferase enzymes: RNA (guanine-N7) methyltransferase (RNMT) and METTL3/METTL14. The research aims to uncover the molecular mechanisms governing how post-translational...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $453,750 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to investigate the connections between one-carbon metabolism, S-adenosyl-methionine (SAM) availability, and chromatin methylation. The research aims to reveal how metabolic enzymes and pathways involved in SAM production are regulated and mobilized to provide SAM for site-specific chromatin methylation reactions. This work will provide critical insights into the molecular mechanisms linking cellular metabolism and epigenetic modifications, which play crucial roles in development, differentiation, cancer, and aging. The project will leverage advanced metabolic sensors, mass spectrometry, and biochemical approaches to study these complex interactions over the award period of June 1, 2025 to April 30, 2030.